Literature DB >> 24895889

Mechanistic insights into the substrate recognition of PPO: toward the rational design of effective inhibitors.

Ge-Fei Hao1, Chang-Guo Zhan, Guang-Fu Yang.   

Abstract

Entities:  

Keywords:  agricultural herbicide; inhibitor design; photodynamic therapy; resistance; substrate recognition; variegated porphyria

Mesh:

Substances:

Year:  2014        PMID: 24895889      PMCID: PMC4367858          DOI: 10.4155/fmc.14.29

Source DB:  PubMed          Journal:  Future Med Chem        ISSN: 1756-8919            Impact factor:   3.808


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  15 in total

1.  The domain structure of protoporphyrinogen oxidase, the molecular target of diphenyl ether-type herbicides.

Authors:  S Arnould; J M Camadro
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

Review 2.  The acute porphyrias.

Authors:  G H Elder; R J Hift; P N Meissner
Journal:  Lancet       Date:  1997-05-31       Impact factor: 79.321

3.  The enzymic conversion of protoporphyrinogen IX to protoporphyrin IX in mammalian mitochondria.

Authors:  R Poulson
Journal:  J Biol Chem       Date:  1976-06-25       Impact factor: 5.157

4.  Photodynamic therapy using a protoporphyrinogen oxidase inhibitor.

Authors:  V H Fingar; T J Wieman; K S McMahon; P S Haydon; B P Halling; D A Yuhas; J W Winkelman
Journal:  Cancer Res       Date:  1997-10-15       Impact factor: 12.701

Review 5.  Porphyrias.

Authors:  Hervé Puy; Laurent Gouya; Jean-Charles Deybach
Journal:  Lancet       Date:  2010-03-13       Impact factor: 79.321

6.  A R59W mutation in human protoporphyrinogen oxidase results in decreased enzyme activity and is prevalent in South Africans with variegate porphyria.

Authors:  P N Meissner; T A Dailey; R J Hift; M Ziman; A V Corrigall; A G Roberts; D M Meissner; R E Kirsch; H A Dailey
Journal:  Nat Genet       Date:  1996-05       Impact factor: 38.330

Review 7.  Structure-based methods for predicting target mutation-induced drug resistance and rational drug design to overcome the problem.

Authors:  Ge-Fei Hao; Guang-Fu Yang; Chang-Guo Zhan
Journal:  Drug Discov Today       Date:  2012-07-10       Impact factor: 7.851

8.  Computational mutation scanning and drug resistance mechanisms of HIV-1 protease inhibitors.

Authors:  Ge-Fei Hao; Guang-Fu Yang; Chang-Guo Zhan
Journal:  J Phys Chem B       Date:  2010-07-29       Impact factor: 2.991

9.  The enzymatic defect in variegate prophyria. Studies with human cultured skin fibroblasts.

Authors:  D A Brenner; J R Bloomer
Journal:  N Engl J Med       Date:  1980-04-03       Impact factor: 91.245

10.  Quantitative structural insight into human variegate porphyria disease.

Authors:  Baifan Wang; Xin Wen; Xiaohong Qin; Zhifang Wang; Ying Tan; Yuequan Shen; Zhen Xi
Journal:  J Biol Chem       Date:  2013-03-06       Impact factor: 5.157

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