BACKGROUND AND AIMS: While hepatitis C virus (HCV) infection has been implicated in increasing the risk of coronary artery disease (CAD), conflicting reports exist regarding this association. We performed a systematic review to further investigate this association. METHODS: We conducted a PubMed search of original research articles from January 1, 1995 to June 30, 2013 to identify case-control and cohort studies evaluating the association between HCV and CAD using keyword terms ["hepatitis c" or "HCV"] and ["coronary artery disease" or "heart disease" or "atherosclerosis."] The primary CAD-related endpoints included myocardial infarction, congestive heart failure, need for coronary artery bypass grafting, or transluminal percutaneous coronary angioplasty. Binary outcomes are reported as odds ratios (OR) with 95 % confidence interval (CI). RESULTS: We identified five studies (four cohort studies and one case-control study) that met our inclusion criteria. A significant association between HCV and CAD was demonstrated in one cohort study (adjusted HR 1.27; 95 % CI 1.22-1.31). One cohort study demonstrated a decreased risk of CAD associated with HCV (adjusted OR 0.74; 95 % CI 0.71-0.76). The remaining studies did not find a significant association between HCV and risk of CAD. CONCLUSIONS: The current systematic review demonstrates that the association between HCV and CAD remains unclear. We need more large, long-term cohort studies with clear definitions of patient population and endpoints to better ascertain the association between HCV and CAD.
BACKGROUND AND AIMS: While hepatitis C virus (HCV) infection has been implicated in increasing the risk of coronary artery disease (CAD), conflicting reports exist regarding this association. We performed a systematic review to further investigate this association. METHODS: We conducted a PubMed search of original research articles from January 1, 1995 to June 30, 2013 to identify case-control and cohort studies evaluating the association between HCV and CAD using keyword terms ["hepatitis c" or "HCV"] and ["coronary artery disease" or "heart disease" or "atherosclerosis."] The primary CAD-related endpoints included myocardial infarction, congestive heart failure, need for coronary artery bypass grafting, or transluminal percutaneous coronary angioplasty. Binary outcomes are reported as odds ratios (OR) with 95 % confidence interval (CI). RESULTS: We identified five studies (four cohort studies and one case-control study) that met our inclusion criteria. A significant association between HCV and CAD was demonstrated in one cohort study (adjusted HR 1.27; 95 % CI 1.22-1.31). One cohort study demonstrated a decreased risk of CAD associated with HCV (adjusted OR 0.74; 95 % CI 0.71-0.76). The remaining studies did not find a significant association between HCV and risk of CAD. CONCLUSIONS: The current systematic review demonstrates that the association between HCV and CAD remains unclear. We need more large, long-term cohort studies with clear definitions of patient population and endpoints to better ascertain the association between HCV and CAD.
Authors: Luigi E Adinolfi; Luciano Restivo; Rosa Zampino; Barbara Guerrera; Amedeo Lonardo; Laura Ruggiero; Francesco Riello; Paola Loria; Anna Florio Journal: Atherosclerosis Date: 2012-02-08 Impact factor: 5.162
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Authors: Adeel A Butt; Wang Xiaoqiang; Matthew Budoff; David Leaf; Lewis H Kuller; Amy C Justice Journal: Clin Infect Dis Date: 2009-07-15 Impact factor: 9.079
Authors: Adeel A Butt; Peng Yan; Kara W Chew; Judith Currier; Kathleen Corey; Raymond T Chung; Ashfaq Shuaib; Abdul-Badi Abou-Samra; Javed Butler; Matthew S Freiberg Journal: Clin Infect Dis Date: 2017-08-15 Impact factor: 9.079
Authors: Juan Berenguer; Elena Rodríguez-Castellano; Ana Carrero; Miguel A Von Wichmann; Marta Montero; María J Galindo; Josep Mallolas; Manuel Crespo; María J Téllez; Carmen Quereda; José Sanz; Carlos Barros; Cristina Tural; Ignacio Santos; Federico Pulido; Josep M Guardiola; Rafael Rubio; Enrique Ortega; María L Montes; Juan J Jusdado; Gabriel Gaspar; Herminia Esteban; José M Bellón; Juan González-García Journal: Hepatology Date: 2017-06-22 Impact factor: 17.425