Yi Tang1, Hui Zhong, Yongshu Diao, Min Qin, Xueli Zhou. 1. Division of Nephrology, West China Hospital of Sichuan University, Chengdu, 610041, Sichuan, People's Republic of China, tmka1986@163.com.
Abstract
BACKGROUND: Peritoneal protein clearance (Pcl) is related to the mortality of patients on continuous ambulatory peritoneal dialysis (CAPD) as well as technique failure. In this prospective observational study, we aimed to investigate factors associated with the level of Pcl. METHODS: We prospectively enrolled 344 prevalent CAPD patients. A standard peritoneal equilibrium test was conducted for each patient. Baseline demographics, biochemistry, and Pcl were recorded. RESULTS: The average Pcl of the patients was 97.40 ± 54.14 mL/day. Peritoneal transport level, serum high-sensitivity C-reactive protein (hsCRP), and residual glomerular filtration rate (rGFR) were independently related to Pcl. The standard β values were 0.53, 0.17, and -0.10, respectively. Moreover, compared with non-diabetic patients, diabetic patients had a non-significantly higher level of Pcl (104.90 ± 48.65 vs. 96.15 ± 54.97 mL/day; P = 0.06). CONCLUSION: Continuous ambulatory peritoneal dialysis patients lose a high amount of protein through the peritoneum each day. The Pcl value is positively related to the level of peritoneal transport and hsCRP and negatively related to the rGFR.
BACKGROUND: Peritoneal protein clearance (Pcl) is related to the mortality of patients on continuous ambulatory peritoneal dialysis (CAPD) as well as technique failure. In this prospective observational study, we aimed to investigate factors associated with the level of Pcl. METHODS: We prospectively enrolled 344 prevalent CAPD patients. A standard peritoneal equilibrium test was conducted for each patient. Baseline demographics, biochemistry, and Pcl were recorded. RESULTS: The average Pcl of the patients was 97.40 ± 54.14 mL/day. Peritoneal transport level, serum high-sensitivity C-reactive protein (hsCRP), and residual glomerular filtration rate (rGFR) were independently related to Pcl. The standard β values were 0.53, 0.17, and -0.10, respectively. Moreover, compared with non-diabeticpatients, diabeticpatients had a non-significantly higher level of Pcl (104.90 ± 48.65 vs. 96.15 ± 54.97 mL/day; P = 0.06). CONCLUSION: Continuous ambulatory peritoneal dialysis patients lose a high amount of protein through the peritoneum each day. The Pcl value is positively related to the level of peritoneal transport and hsCRP and negatively related to the rGFR.
Authors: Olga Balafa; Nynke Halbesma; Dirk G Struijk; Friedo W Dekker; Raymond T Krediet Journal: Clin J Am Soc Nephrol Date: 2010-11-11 Impact factor: 8.237
Authors: Anabela Malho Guedes; Roberto Calças Marques; Brigitte Ribeiro; Mónica T Fernandes; Marília Faísca; Ana Paula Silva; José Bragança; Anabela Rodrigues Journal: Front Med (Lausanne) Date: 2022-05-26