OBJECTIVE: To contrast the prevalence of mild cognitive impairment (MCI) as diagnosed using DSM-5 criteria (DSM5-MCI) with MCI as diagnosed using Petersen's criteria (P-MCI) and to explore the association of both with non-cognitive psychopathological symptoms (NCPS). METHOD: A two-phase epidemiological screening was implemented in a population-based sample of individuals aged 55+ (n = 4803). The Geriatric Mental State (GMS) was the main psychopathological instrument used, and AGECAT was used to make psychiatric diagnoses. Research psychiatrists diagnosed DSM5-MCI and P-MCI using operational criteria. Logistic regression models were then used to investigate the association of MCI with anxiety and depression and with NCPS. RESULTS: Weighted prevalence of DSM5-MCI and P-MCI was, respectively, 3.72% and 7.93% for the aged 65+. NCPS were common in both MCI categories, but negative-type symptoms such as 'anergia' and 'observed slowness' were considerably more frequent among persons with DSM5-MCI. Anxiety and depression diagnostic categories were associated with both P-MCI and DSM5-MCI, but affective-type symptoms were mainly associated with P-MCI. Some negative-type symptoms were inversely associated with P-MCI, and no association was observed with DSM5-MCI. CONCLUSION: The prevalence of DSM5-MCI was half that of P-MCI. Negative-type NCPS were more frequently and typically associated with DSM5-MCI.
OBJECTIVE: To contrast the prevalence of mild cognitive impairment (MCI) as diagnosed using DSM-5 criteria (DSM5-MCI) with MCI as diagnosed using Petersen's criteria (P-MCI) and to explore the association of both with non-cognitive psychopathological symptoms (NCPS). METHOD: A two-phase epidemiological screening was implemented in a population-based sample of individuals aged 55+ (n = 4803). The Geriatric Mental State (GMS) was the main psychopathological instrument used, and AGECAT was used to make psychiatric diagnoses. Research psychiatrists diagnosed DSM5-MCI and P-MCI using operational criteria. Logistic regression models were then used to investigate the association of MCI with anxiety and depression and with NCPS. RESULTS: Weighted prevalence of DSM5-MCI and P-MCI was, respectively, 3.72% and 7.93% for the aged 65+. NCPS were common in both MCI categories, but negative-type symptoms such as 'anergia' and 'observed slowness' were considerably more frequent among persons with DSM5-MCI. Anxiety and depression diagnostic categories were associated with both P-MCI and DSM5-MCI, but affective-type symptoms were mainly associated with P-MCI. Some negative-type symptoms were inversely associated with P-MCI, and no association was observed with DSM5-MCI. CONCLUSION: The prevalence of DSM5-MCI was half that of P-MCI. Negative-type NCPS were more frequently and typically associated with DSM5-MCI.
Authors: J Santabárbara; R Lopez-Anton; P Gracia-García; C De-la-Cámara; D Vaquero-Puyuelo; E Lobo; G Marcos; L Salvador-Carulla; T Palomo; N Sartorius; A Lobo Journal: Epidemiol Psychiatr Sci Date: 2015-10-15 Impact factor: 6.892
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Authors: Perminder S Sachdev; Darren M Lipnicki; Nicole A Kochan; John D Crawford; Anbupalam Thalamuthu; Gavin Andrews; Carol Brayne; Fiona E Matthews; Blossom C M Stephan; Richard B Lipton; Mindy J Katz; Karen Ritchie; Isabelle Carrière; Marie-Laure Ancelin; Linda C W Lam; Candy H Y Wong; Ada W T Fung; Antonio Guaita; Roberta Vaccaro; Annalisa Davin; Mary Ganguli; Hiroko Dodge; Tiffany Hughes; Kaarin J Anstey; Nicolas Cherbuin; Peter Butterworth; Tze Pin Ng; Qi Gao; Simone Reppermund; Henry Brodaty; Nicole Schupf; Jennifer Manly; Yaakov Stern; Antonio Lobo; Raúl Lopez-Anton; Javier Santabárbara Journal: PLoS One Date: 2015-11-05 Impact factor: 3.240
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