Literature DB >> 24893951

Mechanism of drug-induced gingival overgrowth revisited: a unifying hypothesis.

R S Brown1, P R Arany.   

Abstract

Drug-induced gingival overgrowth (DIGO) is a disfiguring side effect of anti-convulsants, calcineurin inhibitors, and calcium channel blocking agents. A unifying hypothesis has been constructed which begins with cation flux inhibition induced by all three of these drug categories. Decreased cation influx of folic acid active transport within gingival fibroblasts leads to decreased cellular folate uptake, which in turn leads to changes in matrix metalloproteinases metabolism and the failure to activate collagenase. Decreased availability of activated collagenase results in decreased degradation of accumulated connective tissue which presents as DIGO. Studies supporting this hypothesis are discussed.
© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Entities:  

Keywords:  calcineurin inhibitors; calcium channel blocking agents; drug-induced gingival overgrowth; folic acid; matrix metalloproteins; phenytoin

Mesh：

Substances：

Year:  2014        PMID： 24893951      PMCID： PMC5241888          DOI： 10.1111/odi.12264

Source DB:  PubMed          Journal:  Oral Dis        ISSN： 1354-523X            Impact factor:   3.511


  119 in total

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Authors:  Hangyuan Guo; Jong-Dae Lee; Hiroyasu Uzui; Hong Yue; Junbo Wang; Kiyohiro Toyoda; Tooru Geshi; Takanori Ueda
Journal:  Circ J       Date:  2006-01       Impact factor: 2.993

2.  The role of inflammation in the pathogenesis of gingival enlargement during the administration of diphenylhydantoin sodium in cats.

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Journal:  J Periodontal Res       Date:  1972       Impact factor: 4.419

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Journal:  Biochim Biophys Acta       Date:  1980-08-01

Review 4.  Phenytoin-induced gingival overgrowth.

Authors:  R Arya; S Gulati
Journal:  Acta Neurol Scand       Date:  2011-06-09       Impact factor: 3.209

5.  Protein synthesis in human reticulocytes induced by therapy of megaloblastic anemia.

Authors:  E R Burka; P A Marks
Journal:  Blood       Date:  1967-10       Impact factor: 22.113

6.  Cyclosporine-A inhibits MMP-2 and -9 activities in the presence of Porphyromonas gingivalis lipopolysaccharide: an experiment in human gingival fibroblast and U937 macrophage co-culture.

Authors:  P-J Kuo; H-P Tu; Y-T Chin; S-H Lu; C-Y Chiang; R-Y Chen; E Fu
Journal:  J Periodontal Res       Date:  2012-02-09       Impact factor: 4.419

7.  Gingival fibroblasts degrade type I collagen films when stimulated with tumor necrosis factor and interleukin 1: evidence that breakdown is mediated by metalloproteinases.

Authors:  M C Meikle; S J Atkinson; R V Ward; G Murphy; J J Reynolds
Journal:  J Periodontal Res       Date:  1989-05       Impact factor: 4.419

8.  Cyclosporine A inhibits the expression of membrane type-I matrix metalloproteinase in gingiva.

Authors:  H-C Chiu; Y-T Lu; Y-T Chin; H-P Tu; C-Y Chiang; C-H Gau; S Nieh; E Fu
Journal:  J Periodontal Res       Date:  2009-02-06       Impact factor: 4.419

9.  Suppression of LPS-induced matrix-metalloproteinase responses in macrophages exposed to phenytoin and its metabolite, 5-(p-hydroxyphenyl-), 5-phenylhydantoin.

Authors:  Ryan Serra; Abdel-Ghany Al-Saidi; Nikola Angelov; Salvador Nares
Journal:  J Inflamm (Lond)       Date:  2010-09-15       Impact factor: 4.981

Review 10.  The use of folic acid for the prevention of neural tube defects and other congenital anomalies.

Authors:  R Douglas Wilson; Gregory Davies; Valérie Désilets; Gregory J Reid; Anne Summers; Philip Wyatt; David Young
Journal:  J Obstet Gynaecol Can       Date:  2003-11
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  9 in total

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2.  Drug-Induced Gum Overgrowth With Low-Dose Amlodipine: A Case Report.

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Review 3.  Refining the Mechanism of Drug-Influenced Gingival Enlargement and Its Management.

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4.  Oral Rehabilitation of a Patient With Generalized Inflammatory Gingival Overgrowth Exacerbated by Felodipine: A Case Report.

Authors:  Wan Ahmad Faiz Wan Jamil; Matheel Al-Rawas; Huwaina Abd Ghani; Rabihah Alawi; Yanti Johari
Journal:  Cureus       Date:  2022-04-21

5.  Amlodipine-induced gingival overgrowth in a child after liver transplant.

Authors:  André Guollo; Ana Paula Molina Vivas; Rodrigo Nascimento Lopes; Gilda Porta; Fábio Abreu Alves
Journal:  Autops Case Rep       Date:  2016-09-30

6.  Folate-receptor 1 level in periodontal disease: a pilot study.

Authors:  Duygu Alkan; Berrak Guven; Cigdem Coskun Turer; Umut Balli; Murat Can
Journal:  BMC Oral Health       Date:  2019-10-11       Impact factor: 2.757

7.  Gingival Enlargement Induced by Felodipine Resolves with a Conventional Periodontal Treatment and Drug Modification.

Authors:  Nabil Khzam; David Bailey; Helen S Yie; Mahmoud M Bakr
Journal:  Case Rep Dent       Date:  2016-02-29

8.  On the Cellular and Molecular Mechanisms of Drug-Induced Gingival Overgrowth.

Authors:  Albert Ramírez-Rámiz; Lluís Brunet-LLobet; Eduard Lahor-Soler; Jaume Miranda-Rius
Journal:  Open Dent J       Date:  2017-07-31

Review 9.  Evidence of Drug-Nutrient Interactions with Chronic Use of Commonly Prescribed Medications: An Update.

Authors:  Emily S Mohn; Hua J Kern; Edward Saltzman; Susan H Mitmesser; Diane L McKay
Journal:  Pharmaceutics       Date:  2018-03-20       Impact factor: 6.321
  9 in total

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