Yi-Yao Chang1, Hsiu-Hao Lee2, Chi-Sheng Hung3, Xue-Ming Wu4, Jen-Kuang Lee5, Shuo-Meng Wang6, Min-Tsun Liao7, Ying-Hsien Chen3, Vin-Cent Wu3, Kwan-Dun Wu3, Yen-Hung Lin8. 1. Cardiology Division of Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan. 2. Department of Internal Medicine, Taipei City Hospital, Zhongxing Branch, Taipei, Taiwan; Institution of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan. 3. Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. 4. Department of Internal Medicine, Taoyuan General Hospital, Taoyuan, Taiwan. 5. Department of Laboratory Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan. 6. Department of Urology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. 7. Department of Internal Medicine, National Taiwan University Hospital Yun-Lin Branch, Yun-Lin, Taiwan. 8. Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address: austinr34@gmail.com.
Abstract
OBJECTIVE: To investigate the association between aldosterone and cardiac diastolic dysfunction. DESIGN AND METHODS: We prospectively enrolled 20 patients with primary aldosteronism (PA) and 22 patients with essential hypertension (EH). Plasma aldosterone concentration, plasma renin activity, and 24-h urine aldosterone level were measured. Echocardiography, including tissue Doppler image recordings, was performed. RESULTS: PA patients had a significantly higher left ventricular (LV) mass index and worse LV diastolic function than those in EH patients. Among various measures of aldosterone, log-transformed 24-h urine aldosterone level had the most consistent correlation with diastolic function. CONCLUSIONS: Aldosterone is strongly associated with LV diastolic dysfunction. Twenty-four hour urine aldosterone is a good indicator to evaluate the impact of aldosterone on LV diastolic function.
OBJECTIVE: To investigate the association between aldosterone and cardiac diastolic dysfunction. DESIGN AND METHODS: We prospectively enrolled 20 patients with primary aldosteronism (PA) and 22 patients with essential hypertension (EH). Plasma aldosterone concentration, plasma renin activity, and 24-h urine aldosterone level were measured. Echocardiography, including tissue Doppler image recordings, was performed. RESULTS: PA patients had a significantly higher left ventricular (LV) mass index and worse LV diastolic function than those in EH patients. Among various measures of aldosterone, log-transformed 24-h urine aldosterone level had the most consistent correlation with diastolic function. CONCLUSIONS:Aldosterone is strongly associated with LV diastolic dysfunction. Twenty-four hour urine aldosterone is a good indicator to evaluate the impact of aldosterone on LV diastolic function.
Authors: Jung Soo Lim; Sungha Park; Sung Il Park; Young Taik Oh; Eunhee Choi; Jang Young Kim; Yumie Rhee Journal: Endocrinol Metab (Seoul) Date: 2016-11-03