Literature DB >> 24892706

The genetics and immunobiology of IgA nephropathy.

Krzysztof Kiryluk, Jan Novak.   

Abstract

IgA nephropathy (IgAN) represents the leading cause of kidney failure among East Asian populations and the most frequent form of primary glomerulonephritis among Europeans. Patients with IgAN develop characteristic IgA1-containing immune complexes that deposit in the glomerular mesangium, producing progressive kidney injury. Recent studies define IgAN as an autoimmune trait of complex architecture with a strong genetic determination. This Review summarizes new insights into the role of the O-glycosylation pathway, anti-glycan immune response, mucosal immunity, antigen processing and presentation, and the alternative complement pathway in the pathogenesis of IgAN.

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Year:  2014        PMID： 24892706      PMCID： PMC4089454          DOI： 10.1172/JCI74475

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  121 in total

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Authors:  Yoshio N Hall; Eloisa F Fuentes; Glenn M Chertow; Jean L Olson
Journal:  BMC Nephrol       Date:  2004-09-02       Impact factor: 2.388
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  84 in total

1.  Immune regulation of kidney disease in 2015: Updates on immunosuppression in kidney disease.

Authors:  Hans-Joachim Anders
Journal:  Nat Rev Nephrol       Date:  2015-12-14       Impact factor: 28.314

Review 2.  Immunoglobulin A nephropathy: a pathophysiology view.

Authors:  Rafaela Cabral Gonçalves Fabiano; Sérgio Veloso Brant Pinheiro; Ana Cristina Simões E Silva
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Journal:  Semin Immunopathol       Date:  2018-09-14       Impact factor: 9.623

Review 4.  CFHR Gene Variations Provide Insights in the Pathogenesis of the Kidney Diseases Atypical Hemolytic Uremic Syndrome and C3 Glomerulopathy.

Authors:  Peter F Zipfel; Thorsten Wiech; Emma D Stea; Christine Skerka
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Authors:  C Seikrit; T Rauen; J Floege
Journal:  Internist (Berl)       Date:  2019-05       Impact factor: 0.743

6.  How many podocyte autophagosomes are there in immunoglobulin A nephropathy and idiopathic membranous nephropathy?

Authors:  Shikai Liang; Juan Jin; Jianguang Gong; Bo Lin; Yiwen Li; Qiang He
Journal:  Int Urol Nephrol       Date:  2016-08-31       Impact factor: 2.370

Review 7.  Insights into kidney diseases from genome-wide association studies.

Authors:  Matthias Wuttke; Anna Köttgen
Journal:  Nat Rev Nephrol       Date:  2016-08-01       Impact factor: 28.314

8.  Crescentic IgA nephropathy after administration of human monoclonal interleukin-12/23p40 antibody in a patient with Crohn's disease: a case report.

Authors:  Nobuhiro Kanazawa; Yukihiro Wada; Minako Akiyama; Yasuto Shikida; Motonori Sugiyama; Maki Abe; Masayuki Iyoda; Kazuho Honda; Takanori Shibata
Journal:  CEN Case Rep       Date:  2020-02-25

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Authors:  Maurizio Salvadori; Giuseppina Rosso
Journal:  World J Nephrol       Date:  2015-09-06

Review 10.  IgA nephropathy enigma.

Authors:  Jiri Mestecky; Jan Novak; Zina Moldoveanu; Milan Raska
Journal:  Clin Immunol       Date:  2016-07-18       Impact factor: 3.969
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