Literature DB >> 24892696

Lack of BCG vaccination and other risk factors for bacteraemia in severely malnourished children with pneumonia.

M J Chisti1, M A Salam2, T Ahmed1, A S M S B Shahid1, K M Shahunja1, A S G Faruque1, P K Bardhan1, M I Hossain1, M M Islam1, S K Das1, S Huq1, L Shahrin1, E Huq3, F Chowdhury4, H Ashraf1.   

Abstract

We sought to examine the factors associated with bacteraemia and their outcome in children with pneumonia and severe acute malnutrition (SAM). All SAM children of either sex, aged 0-59 months, admitted to the Dhaka Hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh with radiologically confirmed pneumonia from April 2011 to July 2012 were enrolled (n = 405). Comparison was made between pneumonic SAM children with (cases = 18), and without (controls = 387) bacteraemia. The death rate was significantly higher in cases than controls (28% vs. 8%, P < 0·01). In logistic regression analysis, after adjusting for potential confounders, the SAM children with pneumonia and bacteraemia more often had a history of lack of bacillus Calmette-Guérin (BCG) vaccination (odds ratio 7·39, 95% confidence interval 1·67-32·73, P < 0·01). The results indicate the importance of continuation of BCG vaccination which may provide benefit beyond its primary purpose.

Entities:  

Keywords:  severe acute malnutrition

Mesh：

Substances：

Year:  2014        PMID： 24892696      PMCID： PMC9507086          DOI： 10.1017/S0950268814001368

Source DB:  PubMed          Journal:  Epidemiol Infect        ISSN： 0950-2688            Impact factor:   4.434


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