CONTEXT: The ocular perceivers are the most voluntarily accessible organs in terms of location in the body, yet drug distribution to these tissues is one of the most intriguing and challenging endeavors and problematic to the pharmaceutical scientist. The most of ocular diseases are treated with topical application of conventional formulation, i.e. solutions, suspensions and ointment. Typically on installation of these conventional formulations, only <5% of the applied dose penetrates the cornea and reaches intraocular tissues, while a major fraction of the instilled dose is wastage due to the presence of many ocular barriers like external barriers, rapid loss of the instilled solution from the precorneal area and nasolacrimal drainage system. Systemic absorption caused systemic side effects varying from mild to life-threatening events. OBJECTIVE: The main objective of this review is to explore the role of colloidal delivery of drug to minimize the drawbacks associated with them. METHODS: This review provides an insight into the various constraints associated with ocular drug delivery, summarizes recent findings and applications of colloidal delivery systems, i.e. nanoparticles, nanosuspensions, liposomes, niosomes, dendrimers and contact lenses containing nanoparticles have the capacity to distribute ocular drugs to categorical target sites and hold promise to revolutionize the therapy of many ocular perceiver diseases and minimized the circumscription of conventional delivery. CONCLUSION: Form the basis of literature review, it has been found that the novel delivery system have greater impact to maximize ocular drug absorption, and minimize systemic absorption and side effects.
CONTEXT: The ocular perceivers are the most voluntarily accessible organs in terms of location in the body, yet drug distribution to these tissues is one of the most intriguing and challenging endeavors and problematic to the pharmaceutical scientist. The most of ocular diseases are treated with topical application of conventional formulation, i.e. solutions, suspensions and ointment. Typically on installation of these conventional formulations, only <5% of the applied dose penetrates the cornea and reaches intraocular tissues, while a major fraction of the instilled dose is wastage due to the presence of many ocular barriers like external barriers, rapid loss of the instilled solution from the precorneal area and nasolacrimal drainage system. Systemic absorption caused systemic side effects varying from mild to life-threatening events. OBJECTIVE: The main objective of this review is to explore the role of colloidal delivery of drug to minimize the drawbacks associated with them. METHODS: This review provides an insight into the various constraints associated with ocular drug delivery, summarizes recent findings and applications of colloidal delivery systems, i.e. nanoparticles, nanosuspensions, liposomes, niosomes, dendrimers and contact lenses containing nanoparticles have the capacity to distribute ocular drugs to categorical target sites and hold promise to revolutionize the therapy of many ocular perceiver diseases and minimized the circumscription of conventional delivery. CONCLUSION: Form the basis of literature review, it has been found that the novel delivery system have greater impact to maximize ocular drug absorption, and minimize systemic absorption and side effects.
Authors: Tivadar Bíró; Alexandra Bocsik; Bisera Jurišić Dukovski; Ilona Gróf; Jasmina Lovrić; Ildikó Csóka; Mária A Deli; Zoltán Aigner Journal: Drug Des Devel Ther Date: 2021-02-03 Impact factor: 4.162
Authors: Aditya Belamkar; Alon Harris; Ryan Zukerman; Brent Siesky; Francesco Oddone; Alice Verticchio Vercellin; Thomas A Ciulla Journal: Ann Med Date: 2022-12 Impact factor: 4.709
Authors: Courtney R Lynch; Pierre P D Kondiah; Yahya E Choonara; Lisa C du Toit; Naseer Ally; Viness Pillay Journal: Front Bioeng Biotechnol Date: 2020-03-20