| Literature DB >> 24891166 |
Sann Yu Mon1, Steven P Hodak2.
Abstract
Molecular diagnostics offers great promise for the evaluation of cytologically indeterminate thyroid nodules. Numerous molecular genetic and immunohistochemical tests have been developed that may be performed on thyroid specimens obtained during standard fine-needle aspiration, some of which may greatly improve diagnostic yield. A sound understanding of the diagnostic performance of these tests, and how they can enhance clinical practice, is important. This article reviews the diagnostic utility of immunohistochemical and molecular testing for the clinical assessment of thyroid nodules, and makes recommendations about how these tests can be integrated into clinical practice for patients with cytologically indeterminate thyroid nodules.Entities:
Keywords: Atypia of uncertain significance/follicular lesion of uncertain significance; Follicular neoplasm/suspicious for follicular neoplasm; Genetic mutations in thyroid cancer; Immunohistochemical tests; Molecular diagnosis for thyroid nodules; Suspicious for malignant cells
Mesh：
Year: 2014 PMID： 24891166 DOI： 10.1016/j.ecl.2014.02.015
Source DB: PubMed Journal: Endocrinol Metab Clin North Am ISSN： 0889-8529 Impact factor: 4.741