Literature DB >> 24890833

MYC and the control of DNA replication.

David Dominguez-Sola1, Jean Gautier2.   

Abstract

The MYC oncogene is a multifunctional protein that is aberrantly expressed in a significant fraction of tumors from diverse tissue origins. Because of its multifunctional nature, it has been difficult to delineate the exact contributions of MYC's diverse roles to tumorigenesis. Here, we review the normal role of MYC in regulating DNA replication as well as its ability to generate DNA replication stress when overexpressed. Finally, we discuss the possible mechanisms by which replication stress induced by aberrant MYC expression could contribute to genomic instability and cancer.
Copyright © 2014 Cold Spring Harbor Laboratory Press; all rights reserved.

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Year:  2014        PMID： 24890833      PMCID： PMC4031955          DOI： 10.1101/cshperspect.a014423

Source DB:  PubMed          Journal:  Cold Spring Harb Perspect Med        ISSN： 2157-1422            Impact factor:   6.915


  202 in total

1.  Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoter.

Authors:  C Bouchard; O Dittrich; A Kiermaier; K Dohmann; A Menkel; M Eilers; B Lüscher
Journal:  Genes Dev       Date:  2001-08-15       Impact factor: 11.361

2.  Human gene organization driven by the coordination of replication and transcription.

Authors:  Maxime Huvet; Samuel Nicolay; Marie Touchon; Benjamin Audit; Yves d'Aubenton-Carafa; Alain Arneodo; Claude Thermes
Journal:  Genome Res       Date:  2007-08-03       Impact factor: 9.043

3.  ATM promotes apoptosis and suppresses tumorigenesis in response to Myc.

Authors:  Raju V Pusapati; Robert J Rounbehler; SungKi Hong; John T Powers; Mingshan Yan; Kaoru Kiguchi; Mark J McArthur; Paul K Wong; David G Johnson
Journal:  Proc Natl Acad Sci U S A       Date:  2006-01-23       Impact factor: 11.205

4.  Analysis of C-MYC function in normal cells via conditional gene-targeted mutation.

Authors:  I M de Alboran; R C O'Hagan; F Gärtner; B Malynn; L Davidson; R Rickert; K Rajewsky; R A DePinho; F W Alt
Journal:  Immunity       Date:  2001-01       Impact factor: 31.745

5.  ATM and ATR check in on origins: a dynamic model for origin selection and activation.

Authors:  David Shechter; Jean Gautier
Journal:  Cell Cycle       Date:  2005-02-13       Impact factor: 4.534

6.  Role of c-myc in simian virus 40 large tumor antigen-induced DNA synthesis in quiescent 3T3-L1 mouse fibroblasts.

Authors:  H Hermeking; D A Wolf; F Kohlhuber; A Dickmanns; M Billaud; E Fanning; D Eick
Journal:  Proc Natl Acad Sci U S A       Date:  1994-10-25       Impact factor: 11.205

7.  c-MYC delays prometaphase by direct transactivation of MAD2 and BubR1: identification of mechanisms underlying c-MYC-induced DNA damage and chromosomal instability.

Authors:  Antje Menssen; Alexey Epanchintsev; Dmitri Lodygin; Nousin Rezaei; Peter Jung; Berlinda Verdoodt; Joachim Diebold; Heiko Hermeking
Journal:  Cell Cycle       Date:  2007-02-03       Impact factor: 4.534

8.  The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry.

Authors:  Fionnuala Morrish; Nicola Neretti; John M Sedivy; David M Hockenbery
Journal:  Cell Cycle       Date:  2008-02-08       Impact factor: 4.534

Review 9.  Chromosome fragile sites.

Authors:  Sandra G Durkin; Thomas W Glover
Journal:  Annu Rev Genet       Date:  2007       Impact factor: 16.830

10.  H3 k36 methylation helps determine the timing of cdc45 association with replication origins.

Authors:  Fiona Pryde; Devanshi Jain; Alastair Kerr; Rebecca Curley; Francesca Romana Mariotti; Maria Vogelauer
Journal:  PLoS One       Date:  2009-06-12       Impact factor: 3.240
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  31 in total

Review 1.  An overview of MYC and its interactome.

Authors:  Maralice Conacci-Sorrell; Lisa McFerrin; Robert N Eisenman
Journal:  Cold Spring Harb Perspect Med       Date:  2014-01-01       Impact factor: 6.915

2.  Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas.

Authors:  Franz X Schaub; Varsha Dhankani; Ashton C Berger; Mihir Trivedi; Anne B Richardson; Reid Shaw; Wei Zhao; Xiaoyang Zhang; Andrea Ventura; Yuexin Liu; Donald E Ayer; Peter J Hurlin; Andrew D Cherniack; Robert N Eisenman; Brady Bernard; Carla Grandori
Journal:  Cell Syst       Date:  2018-03-28       Impact factor: 10.304

3.  MRE11 Promotes Tumorigenesis by Facilitating Resistance to Oncogene-Induced Replication Stress.

Authors:  Elizabeth Spehalski; Kayla M Capper; Cheryl J Smith; Mary J Morgan; Maria Dinkelmann; Jeffrey Buis; JoAnn M Sekiguchi; David O Ferguson
Journal:  Cancer Res       Date:  2017-08-17       Impact factor: 12.701

Review 4.  Targeting DNA damage repair in small cell lung cancer and the biomarker landscape.

Authors:  Triparna Sen; Carl M Gay; Lauren Averett Byers
Journal:  Transl Lung Cancer Res       Date:  2018-02

5.  Functional interplay between c-Myc and Max in B lymphocyte differentiation.

Authors:  Mercedes Pérez-Olivares; Alfonsina Trento; Sara Rodriguez-Acebes; Daniel González-Acosta; David Fernández-Antorán; Sara Román-García; Dolores Martinez; Tania López-Briones; Carlos Torroja; Yolanda R Carrasco; Juan Méndez; Ignacio Moreno de Alborán
Journal:  EMBO Rep       Date:  2018-08-20       Impact factor: 8.807

6.  HUMORAL IMMUNITY. T cell help controls the speed of the cell cycle in germinal center B cells.

Authors:  Alexander D Gitlin; Christian T Mayer; Thiago Y Oliveira; Ziv Shulman; Mathew J K Jones; Amnon Koren; Michel C Nussenzweig
Journal:  Science       Date:  2015-07-16       Impact factor: 47.728

7.  The Cdk2-c-Myc-miR-571 Axis Regulates DNA Replication and Genomic Stability by Targeting Geminin.

Authors:  Yi Zhang; Zhuqing Li; Qiang Hao; Wei Tan; Jing Sun; Jing Li; Chi-Wei Chen; Zongzhu Li; Yunxiao Meng; Yuan Zhou; Zhiyong Han; Huadong Pei; Melvin L DePamphilis; Wenge Zhu
Journal:  Cancer Res       Date:  2019-08-20       Impact factor: 12.701

Review 8.  MYC activation is a hallmark of cancer initiation and maintenance.

Authors:  Meital Gabay; Yulin Li; Dean W Felsher
Journal:  Cold Spring Harb Perspect Med       Date:  2014-06-02       Impact factor: 6.915

Review 9.  Conceptual frameworks of synthetic lethality in clear cell carcinoma of the ovary.

Authors:  Hiroshi Kobayashi; Naoki Kawahara; Kenji Ogawa; Yuki Yamada; Kana Iwai; Emiko Niiro; Sachiko Morioka
Journal:  Biomed Rep       Date:  2018-06-20

10.  MYC Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition.

Authors:  Tim A Rand; Kenta Sutou; Koji Tanabe; Daeun Jeong; Masaki Nomura; Fumiyo Kitaoka; Emi Tomoda; Megumi Narita; Michiko Nakamura; Masahiro Nakamura; Akira Watanabe; Eric Rulifson; Shinya Yamanaka; Kazutoshi Takahashi
Journal:  Cell Rep       Date:  2018-04-10       Impact factor: 9.423
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