J Jason Bowman1, Peter D Burbelo2, Rachel B Gill1, Michael A Sauri3, James M Schmitt4, Jeffrey I Cohen5. 1. Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States. 2. Neurobiology and Pain Therapeutics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, United States. 3. Occupational Health Consultants, Rockville, MD, United States. 4. Occupational Medical Service, Division of Occupational Safety and Health, Office of the Director, National Institutes of Health, Bethesda, MD, United States. 5. Medical Virology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, United States. Electronic address: jcohen@niaid.nih.gov.
Abstract
BACKGROUND: Human cytomegalovirus (HCMV) infection can cause severe disease in neonates and immunocompromised persons, and infectious mononucleosis in healthy adults. While, rhesus CMV (RhCMV) infects human cells in culture, it is unknown whether the virus can infect humans. OBJECTIVES: We sought to determine whether primate workers, including those with injuries from animals, might be infected asymptomatically with RhCMV. STUDY DESIGN: We developed serologic assays that distinguish RhCMV from HCMV antibodies. We tested two groups of primate workers: those with documented injuries or mucosal splashes associated with rhesus macaques, and those with no documented exposure who worked with these animals. RESULTS: None of over 200 primate workers, including 119 with injuries or mucosal splashes associated with exposures to macaques, were seropositive for RhCMV. CONCLUSIONS: The frequency of asymptomatic RhCMV infection in persons who work with rhesus macaques was <0.5% (<1/200 primate workers). Published by Elsevier B.V.
BACKGROUND:Human cytomegalovirus (HCMV) infection can cause severe disease in neonates and immunocompromised persons, and infectious mononucleosis in healthy adults. While, rhesus CMV (RhCMV) infects human cells in culture, it is unknown whether the virus can infect humans. OBJECTIVES: We sought to determine whether primate workers, including those with injuries from animals, might be infected asymptomatically with RhCMV. STUDY DESIGN: We developed serologic assays that distinguish RhCMV from HCMV antibodies. We tested two groups of primate workers: those with documented injuries or mucosal splashes associated with rhesus macaques, and those with no documented exposure who worked with these animals. RESULTS: None of over 200 primate workers, including 119 with injuries or mucosal splashes associated with exposures to macaques, were seropositive for RhCMV. CONCLUSIONS: The frequency of asymptomatic RhCMV infection in persons who work with rhesus macaques was <0.5% (<1/200 primate workers). Published by Elsevier B.V.
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