| Literature DB >> 24890762 |
P Jayasekera1, R Parslew, A Al-Sharqi.
Abstract
Rituximab, a chimeric B-cell-depleting monoclonal antibody, is a well-established therapy for rheumatoid arthritis. It is emerging that classical psoriatic lesions and plantar pustular psoriasis (PPP) are cutaneous side-effects of this drug. Antitumour necrosis factor (anti-TNF) therapies have multiple documented side-effects including PPP and psoriasis. We report a patient who has rheumatoid arthritis, who failed on anti-TNF therapies and then was commenced on rituximab. Subsequently she developed localized PPP. Due to deterioration of her joint disease she was switched to the interleukin-6 blocker tocilizumab, and the PPP resolved.Entities:
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Year: 2014 PMID: 24890762 DOI: 10.1111/bjd.13146
Source DB: PubMed Journal: Br J Dermatol ISSN: 0007-0963 Impact factor: 9.302