Literature DB >> 24890726

Cutting edge: Parathyroid hormone facilitates macrophage efferocytosis in bone marrow via proresolving mediators resolvin D1 and resolvin D2.

Laurie K McCauley1, Jesmond Dalli2, Amy J Koh3, Nan Chiang2, Charles N Serhan2.   

Abstract

Bone marrow macrophages stimulate skeletal wound repair and osteoblastic bone formation by poorly defined mechanisms. Specialized proresolving mediators of inflammation drive macrophage efferocytosis (phagocytosis of apoptotic cells) and resolution, but little is known regarding this process in the bone marrow. In this study, metabololipidomic profiling via liquid chromatography mass spectrometry revealed higher levels of specialized proresolving mediators in the bone marrow relative to the spleen. The endocrine and bone anabolic agent parathyroid hormone increased specialized proresolving mediator levels, including resolvins (Rvs), in bone marrow. Human and murine primary macrophages efferocytosed apoptotic osteoblasts in vitro, and RvD1 and RvD2 (10 pM-10 nM) enhanced this process. These findings support a unique profile of specialized lipid mediators in bone marrow that contribute to a feedback system for resolution of inflammation and maintenance of skeletal homeostasis.
Copyright © 2014 by The American Association of Immunologists, Inc.

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Year:  2014        PMID： 24890726      PMCID： PMC4285693          DOI： 10.4049/jimmunol.1301945

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  20 in total

Review 1.  Resolution of inflammation: the beginning programs the end.

Authors:  Charles N Serhan; John Savill
Journal:  Nat Immunol       Date:  2005-12       Impact factor: 25.606

2.  Osteal macrophages support physiologic skeletal remodeling and anabolic actions of parathyroid hormone in bone.

Authors:  Sun Wook Cho; Fabiana N Soki; Amy J Koh; Matthew R Eber; Payam Entezami; Serk In Park; Nico van Rooijen; Laurie K McCauley
Journal:  Proc Natl Acad Sci U S A       Date:  2014-01-09       Impact factor: 11.205

3.  Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents.

Authors:  Jesmond Dalli; Jeremy W Winkler; Romain A Colas; Hildur Arnardottir; Chien-Yee C Cheng; Nan Chiang; Nicos A Petasis; Charles N Serhan
Journal:  Chem Biol       Date:  2013-02-21

4.  The soluble interleukin-6 receptor is a mediator of hematopoietic and skeletal actions of parathyroid hormone.

Authors:  Sun Wook Cho; Flavia Q Pirih; Amy J Koh; Megan Michalski; Matthew R Eber; Kathryn Ritchie; Benjamin Sinder; Seojin Oh; Saja A Al-Dujaili; JoonHo Lee; Ken Kozloff; Theodora Danciu; Thomas J Wronski; Laurie K McCauley
Journal:  J Biol Chem       Date:  2013-01-07       Impact factor: 5.157

5.  Dramatic increase in cortical thickness induced by femoral marrow ablation followed by a 3-month treatment with PTH in rats.

Authors:  Qing Zhang; Jodi Carlson; Hua Zhu Ke; Jiliang Li; Michael Kim; Kieran Murphy; Nozer Mehta; James Gilligan; Agnès Vignery
Journal:  J Bone Miner Res       Date:  2010-06       Impact factor: 6.741

6.  Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells.

Authors:  Sesquile Ramon; Fei Gao; Charles N Serhan; Richard P Phipps
Journal:  J Immunol       Date:  2012-06-18       Impact factor: 5.422

7.  Teriparatide for acceleration of fracture repair in humans: a prospective, randomized, double-blind study of 102 postmenopausal women with distal radial fractures.

Authors:  Per Aspenberg; Harry K Genant; Torsten Johansson; Antonio J Nino; Kyoungah See; Kelly Krohn; Pedro A García-Hernández; Christopher P Recknor; Thomas A Einhorn; Gail P Dalsky; Bruce H Mitlak; Anke Fierlinger; Mark C Lakshmanan
Journal:  J Bone Miner Res       Date:  2010-02       Impact factor: 6.741

8.  Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators.

Authors:  Jesmond Dalli; Charles N Serhan
Journal:  Blood       Date:  2012-08-17       Impact factor: 22.113

Review 9.  Prostaglandins in bone: bad cop, good cop?

Authors:  Katherine A Blackwell; Lawrence G Raisz; Carol C Pilbeam
Journal:  Trends Endocrinol Metab       Date:  2010-01-14       Impact factor: 12.015

10.  Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre/osteoclasts.

Authors:  Xin Li; Ling Qin; Marika Bergenstock; Laura M Bevelock; Deborah V Novack; Nicola C Partridge
Journal:  J Biol Chem       Date:  2007-08-09       Impact factor: 5.157
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  26 in total

1.  Resolvin D1, resolvin D2 and maresin 1 activate the GSK3β anti-inflammatory axis in TLR4-engaged human monocytes.

Authors:  Zhen Gu; Gwyneth J Lamont; Richard J Lamont; Silvia M Uriarte; Huizhi Wang; David A Scott
Journal:  Innate Immun       Date:  2016-02-15       Impact factor: 2.680

2.  Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function.

Authors:  Vasundhara Kain; Kevin A Ingle; Romain A Colas; Jesmond Dalli; Sumanth D Prabhu; Charles N Serhan; Medha Joshi; Ganesh V Halade
Journal:  J Mol Cell Cardiol       Date:  2015-04-11       Impact factor: 5.000

Review 3.  Latest perspectives on macrophages in bone homeostasis.

Authors:  Aline Bozec; Didier Soulat
Journal:  Pflugers Arch       Date:  2017-02-28       Impact factor: 3.657

Review 4.  Macrophages and skeletal health.

Authors:  Megan N Michalski; Laurie K McCauley
Journal:  Pharmacol Ther       Date:  2017-02-07       Impact factor: 12.310

5.  Identification and Complete Stereochemical Assignments of the New Resolvin Conjugates in Tissue Regeneration in Human Tissues that Stimulate Proresolving Phagocyte Functions and Tissue Regeneration.

Authors:  Xavier de la Rosa; Paul C Norris; Nan Chiang; Ana R Rodriguez; Bernd W Spur; Charles N Serhan
Journal:  Am J Pathol       Date:  2018-04       Impact factor: 4.307

6.  Bone Mass Is Compromised by the Chemotherapeutic Trabectedin in Association With Effects on Osteoblasts and Macrophage Efferocytosis.

Authors:  Benjamin P Sinder; Laura Zweifler; Amy J Koh; Megan N Michalski; Lorenz C Hofbauer; Jose Ignacio Aguirre; Hernan Roca; Laurie K McCauley
Journal:  J Bone Miner Res       Date:  2017-08-31       Impact factor: 6.741

7.  Novel proresolving and tissue-regenerative resolvin and protectin sulfido-conjugated pathways.

Authors:  Jesmond Dalli; Sesquile Ramon; Paul C Norris; Romain A Colas; Charles N Serhan
Journal:  FASEB J       Date:  2015-02-20       Impact factor: 5.191

Review 8.  Osteoporosis and Periodontitis.

Authors:  Chin-Wei Jeff Wang; Laurie K McCauley
Journal:  Curr Osteoporos Rep       Date:  2016-12       Impact factor: 5.096

9.  Modulation of Osteoblastic Cell Efferocytosis by Bone Marrow Macrophages.

Authors:  Megan N Michalski; Amy J Koh; Savannah Weidner; Hernan Roca; Laurie K McCauley
Journal:  J Cell Biochem       Date:  2016-05-05       Impact factor: 4.429

Review 10.  Macrophages: Their Emerging Roles in Bone.

Authors:  Benjamin P Sinder; Allison R Pettit; Laurie K McCauley
Journal:  J Bone Miner Res       Date:  2015-12       Impact factor: 6.741
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