Literature DB >> 2489072

Inhibitory effect of a synthetic polypeptide, poly(Tyr-Ile-Gly-Ser-Arg), on the metastatic formation of malignant tumour cells.

J Murata1, I Saiki, I Azuma, N Nishi.   

Abstract

A new type of polypeptide containing the repeating sequence of cell attachment site in laminin, poly(Tyr-Ile-Gly-Ser-Arg), was synthesized by the polymerization procedure with diphenylphosphoryl azide (DPPA). We found that this polypeptide inhibited the metastatic formation in the lung of malignant tumour cells far more effectively than pentapeptide.

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Year:  1989        PMID： 2489072     DOI： 10.1016/0141-8130(89)90049-4

Source DB:  PubMed          Journal:  Int J Biol Macromol        ISSN： 0141-8130            Impact factor:   6.953


  6 in total

1.  Phosphorylation mapping of Laminin β1-chain: Kinases in association with active sites.

Authors:  Kleio-Maria Verrou; Panagiota Angeliki Galliou; Maria Papaioannou; Georgios Koliakos
Journal:  J Biosci       Date:  2019-06       Impact factor: 1.826

Review 2.  Basement membrane and the SIKVAV laminin-derived peptide promote tumor growth and metastases.

Authors:  T M Sweeney; M C Kibbey; M Zain; R Fridman; H K Kleinman
Journal:  Cancer Metastasis Rev       Date:  1991-10       Impact factor: 9.264

3.  Antimetastatic effects of synthetic polypeptides containing repeated structures of the cell adhesive Arg-Gly-Asp (RGD) and Tyr-Ile-Gly-Ser-Arg (YIGSR) sequences.

Authors:  I Saiki; J Murata; J Iida; T Sakurai; N Nishi; K Matsuno; I Azuma
Journal:  Br J Cancer       Date:  1989-11       Impact factor: 7.640

4.  The laminin-derived peptide YIGSR (Tyr-Ile-Gly-Ser-Arg) inhibits human pre-B leukaemic cell growth and dissemination to organs in SCID mice.

Authors:  N Yoshida; E Ishii; M Nomizu; Y Yamada; S Mohri; N Kinukawa; A Matsuzaki; K Oshima; T Hara; S Miyazaki
Journal:  Br J Cancer       Date:  1999-08       Impact factor: 7.640

Review 5.  Laminin-111-derived peptides and cancer.

Authors:  Yamato Kikkawa; Kentaro Hozumi; Fumihiko Katagiri; Motoyoshi Nomizu; Hynda K Kleinman; Jennifer E Koblinski
Journal:  Cell Adh Migr       Date:  2012-12-21       Impact factor: 3.405

6.  Inhibition of angiogenesis, tumour growth and experimental metastasis of human fibrosarcoma cells HT1080 by a multimeric form of the laminin sequence Tyr-Ile-Gly-Ser-Arg (YIGSR).

Authors:  Y Iwamoto; M Nomizu; Y Yamada; Y Ito; K Tanaka; Y Sugioka
Journal:  Br J Cancer       Date:  1996-03       Impact factor: 7.640
  6 in total

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