Riccardo Di Domenicantonio1, Giovanna Cappai2, Massimo Arcà2, Nera Agabiti2, Anna Kohn3, Piero Vernia4, Livia Biancone5, Alessandro Armuzzi6, Claudio Papi7, Marina Davoli2. 1. Department of Epidemiology, Regional Health Service, Rome, Italy. Electronic address: r.didomenicantonio@deplazio.it. 2. Department of Epidemiology, Regional Health Service, Rome, Italy. 3. Division of Gastroenterology, AO San Camillo Forlanini, Rome, Italy. 4. Department of Internal Medicine and Medical Specialties, Gastroenterology Unit, Sapienza University of Rome, Rome, Italy. 5. Department of Internal Medicine, Gastroenterology Unit, University Tor Vergata, Rome, Italy. 6. IBD Unit, Complesso Integrato Columbus, Catholic University, Rome, Italy. 7. Division of Gastroenterology, AO San Filippo Neri, Rome, Italy.
Abstract
BACKGROUND: The burden of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, has never been estimated in Italy using administrative data sources. Our objective was to measure the occurrence of inflammatory bowel diseases in the Lazio region (Italy) using administrative data and to test the sensitivity of the Crohn's disease case-finding algorithm with respect to clinical diagnosis. METHODS: We conducted a population-based cross-sectional study identifying prevalent and incident cases. We estimated occurrence rates of inflammatory bowel diseases using hospital discharges or activation of copayment exemptions. Sensitivity was calculated from 2358 subjects with clinical diagnosis of Crohn's disease. RESULTS: Exemptions identified more than 20% of the cases. Prevalence rates (per 100,000) on December 31, 2009 for males and females were 177 and 144 for ulcerative colitis and 91 and 81 for Crohn's disease, respectively. The incidence rates during the years 2008-2009 were 14.5 and 12.2 for ulcerative colitis and 7.4 and 6.5 for Crohn's disease for males and females, respectively. The sensitivity of the administrative sources was 82.2%. CONCLUSIONS: Health and population data sources allow the estimation of inflammatory bowel diseases occurrence. The age-specific peaks of diagnosis were consistent with those reported in other studies. Sensitivity may be affected by temporal changes in the quality of the data sources.
BACKGROUND: The burden of inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, has never been estimated in Italy using administrative data sources. Our objective was to measure the occurrence of inflammatory bowel diseases in the Lazio region (Italy) using administrative data and to test the sensitivity of the Crohn's disease case-finding algorithm with respect to clinical diagnosis. METHODS: We conducted a population-based cross-sectional study identifying prevalent and incident cases. We estimated occurrence rates of inflammatory bowel diseases using hospital discharges or activation of copayment exemptions. Sensitivity was calculated from 2358 subjects with clinical diagnosis of Crohn's disease. RESULTS: Exemptions identified more than 20% of the cases. Prevalence rates (per 100,000) on December 31, 2009 for males and females were 177 and 144 for ulcerative colitis and 91 and 81 for Crohn's disease, respectively. The incidence rates during the years 2008-2009 were 14.5 and 12.2 for ulcerative colitis and 7.4 and 6.5 for Crohn's disease for males and females, respectively. The sensitivity of the administrative sources was 82.2%. CONCLUSIONS: Health and population data sources allow the estimation of inflammatory bowel diseases occurrence. The age-specific peaks of diagnosis were consistent with those reported in other studies. Sensitivity may be affected by temporal changes in the quality of the data sources.
Authors: Daiana Bezzini; L Policardo; F Profili; G Meucci; M Ulivelli; S Bartalini; P Francesconi; M A Battaglia Journal: Neurol Sci Date: 2018-08-08 Impact factor: 3.307
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Authors: A Fattori; L Neri; E Aguglia; A Bellomo; A Bisogno; D Camerino; B Carpiniello; A Cassin; G Costa; P De Fazio; G Di Sciascio; G Favaretto; C Fraticelli; R Giannelli; S Leone; T Maniscalco; C Marchesi; M Mauri; C Mencacci; G Polselli; R Quartesan; F Risso; A Sciaretta; M Vaggi; S Vender; U Viora Journal: Biomed Res Int Date: 2015-10-18 Impact factor: 3.411