| Literature DB >> 24888986 |
Yuhei Shimizu1, Megumi Noshita, Yuri Mukai, Hiroyuki Morimoto, Takashi Ohshima.
Abstract
Hydrazinolysis of unactivated amide bonds is significantly accelerated by the addition of ammonium salts. The reactions proceed at 50-70 °C to give amines with broad substrate scope that outperforms existing amide bond cleavage reactions. Application to peptide and amino sugar derivatives is also demonstrated.Entities:
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Year: 2014 PMID： 24888986 DOI： 10.1039/c4cc02014f
Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222