Literature DB >> 24884829

Changes in PKM2 associate with prostate cancer progression.

Nicholas Wong1, Judy Yan, Diane Ojo, Jason De Melo, Jean-Claude Cutz, Damu Tang.   

Abstract

Pyruvate kinase M2 (PKM2) is essential for aerobic glycolysis, the dominant metabolic pathway utilized by cancer cells. To determine the association of PKM2 with prostate cancer (PC), we examined 29 primary PC and three lymph node metastatic tumors; elevation of PKM2 was observed in Gleason 8-10 tumors compared to Gleason 6-7 carcinomas. High PKM2 was detected by immunohistochemistry in more aggressive xenograft tumors derived from PC stem-like cells (PCSCs) compared to those produced from non-PCSCs. While PCSCs and non-PCSCs expressed comparable levels of PKM2, distinct posttranslational modifications were observed. Collectively, upregulation and specific modification to PKM2 associate with PC progression.

Entities:  

Keywords:  Cancer Metabolism; PKM2; Prostate cancer

Mesh：

Substances：

Year:  2014        PMID： 24884829     DOI： 10.3109/07357907.2014.919306

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  18 in total

1.  The Utility of [18F]DASA-23 for Molecular Imaging of Prostate Cancer with Positron Emission Tomography.

Authors:  Corinne Beinat; Tom Haywood; Yun-Sheng Chen; Chirag B Patel; Israt S Alam; Surya Murty; Sanjiv Sam Gambhir
Journal:  Mol Imaging Biol       Date:  2018-12       Impact factor: 3.488

2.  Reversal of the Warburg phenomenon in chemoprevention of prostate cancer by sulforaphane.

Authors:  Krishna B Singh; Eun-Ryeong Hahm; Joshi J Alumkal; Lesley M Foley; T Kevin Hitchens; Sruti S Shiva; Rahul A Parikh; Bruce L Jacobs; Shivendra V Singh
Journal:  Carcinogenesis       Date:  2019-12-31       Impact factor: 4.944

3.  Overexpression of metabolic markers HK1 and PKM2 contributes to lymphatic metastasis and adverse prognosis in Chinese gastric cancer.

Authors:  Yunshu Gao; Dongyun Xu; Guanzhen Yu; Jun Liang
Journal:  Int J Clin Exp Pathol       Date:  2015-08-01

4.  Expression of pyruvate kinase M2 in human colorectal cancer and its prognostic value.

Authors:  Rong Cui; Xing-Yao Shi
Journal:  Int J Clin Exp Pathol       Date:  2015-09-01

5.  Pyruvate kinase M2 prevents apoptosis via modulating Bim stability and associates with poor outcome in hepatocellular carcinoma.

Authors:  Wen Hu; Shi-Xun Lu; Min Li; Chao Zhang; Li-Li Liu; Jia Fu; Jie-Tian Jin; Rong-Zhen Luo; Chris Zhiyi Zhang; Jing-Ping Yun
Journal:  Oncotarget       Date:  2015-03-30

6.  Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies.

Authors:  Jiayuan Wu; Liren Hu; Manyu Chen; Wenjun Cao; Haicong Chen; Taiping He
Journal:  Onco Targets Ther       Date:  2016-07-14       Impact factor: 4.147

Review 7.  Oxidative stress in prostate hyperplasia and carcinogenesis.

Authors:  Udensi K Udensi; Paul B Tchounwou
Journal:  J Exp Clin Cancer Res       Date:  2016-09-08

8.  Targeting stromal-induced pyruvate kinase M2 nuclear translocation impairs oxphos and prostate cancer metastatic spread.

Authors:  Elisa Giannoni; Maria Letizia Taddei; Andrea Morandi; Giuseppina Comito; Maura Calvani; Francesca Bianchini; Barbara Richichi; Giovanni Raugei; Nicholas Wong; Damu Tang; Paola Chiarugi
Journal:  Oncotarget       Date:  2015-09-15

9.  PKM2 and cancer: The function of PKM2 beyond glycolysis.

Authors:  Gaochao Dong; Qixing Mao; Wenjie Xia; Youtao Xu; Jie Wang; Lin Xu; Feng Jiang
Journal:  Oncol Lett       Date:  2016-01-29       Impact factor: 2.967

10.  LY294002 inhibits the Warburg effect in gastric cancer cells by downregulating pyruvate kinase M2.

Authors:  Jian Lu; Min Chen; Sumeng Gao; Jigang Yuan; Zhu Zhu; Xiaoping Zou
Journal:  Oncol Lett       Date:  2018-01-23       Impact factor: 2.967
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