Modifications of blood rheology during aging and age-related pathological conditions.

In principle there should not be any increase of blood viscosity factors (plasma viscosity, blood viscosity, aggregation of red blood cells, rigidity of red blood cells, dynamic thrombus formation) with aging in a healthy population. Such an increase would be due to pathological caused and not to aging per se. The pathological causes of the increase in the blood viscosity factors often observed in the elderly could be ascribed to the following: use of drugs (e.g. cigarette smoking); lack of exercise; unbalanced diet; psychological states such as anxiety and depression; presence of diseases such as heart disease or cancer or diabetes (although these disorders have the same effect in a younger population). The principal viscosity factors are explained, and their role in tissue perfusion, occlusions, infarctions and other disorders is described. This review will hopefully serve as an introduction to the studies of the haemorheology of aging. A counteraction of the elevation of blood viscosity factors might be helpful in ameliorating many diseases typical of aging, and should allow elderly people to remain active much longer.