Phillip S Helliwell1, Oliver FitzGerald2, Jaap Fransen2. 1. From the University of Leeds, Leeds, UK, and Bradford Hospitals National Health Service (NHS) Foundation Trust, Bradford, UK; Department of Rheumatology, St. Vincent's University Hospital, Elm Park, Dublin, Ireland; Department of Rheumatology, Radboud University Medical Centre, Nijmegen, The Netherlands.P.S. Helliwell, DM, PhD, FRCP, Senior Lecturer in Rheumatology, University of Leeds and Bradford Hospitals NHS Foundation Trust; O. FitzGerald, MD, FRCPI, FRCP(UK), Newman Clinical Research Professor, Department of Rheumatology, St. Vincent's University Hospital; J. Fransen, PhD, Department of Rheumatology, Radboud University Medical Centre. p.helliwell@leeds.ac.uk. 2. From the University of Leeds, Leeds, UK, and Bradford Hospitals National Health Service (NHS) Foundation Trust, Bradford, UK; Department of Rheumatology, St. Vincent's University Hospital, Elm Park, Dublin, Ireland; Department of Rheumatology, Radboud University Medical Centre, Nijmegen, The Netherlands.P.S. Helliwell, DM, PhD, FRCP, Senior Lecturer in Rheumatology, University of Leeds and Bradford Hospitals NHS Foundation Trust; O. FitzGerald, MD, FRCPI, FRCP(UK), Newman Clinical Research Professor, Department of Rheumatology, St. Vincent's University Hospital; J. Fransen, PhD, Department of Rheumatology, Radboud University Medical Centre.
Abstract
OBJECTIVE: There are several new composite indices for assessing disease activity in psoriatic arthritis (PsA). Each may function as a disease state variable and a responder index. The aim of our study was to determine cutoffs for disease activity and response. METHODS: Data from the Group for GRAPPA Composite Exercise (GRACE) study were used to develop cutoffs using a number of different approaches. Voting on choice of cutoff was undertaken at the 2013 GRAPPA Annual Meeting in Toronto, Ontario, Canada. RESULTS: After voting, results for cutoffs for low/high disease activity for the Psoriatic ArthritiS Disease Activity Score (PASDAS), GRAppa Composite scorE (GRACE index), and Composite Psoriatic Disease Activity Index (CPDAI), respectively, were 3.2/5.4, 2.3/4.7, and 4/8. The measurement error for each composite score was estimated at 0.8, 1, and 2 for PASDAS, GRACE, and CPDAI, respectively. CONCLUSION: Response criteria for the new composite indices have been developed. These now require further validation and testing in other datasets.
OBJECTIVE: There are several new composite indices for assessing disease activity in psoriatic arthritis (PsA). Each may function as a disease state variable and a responder index. The aim of our study was to determine cutoffs for disease activity and response. METHODS: Data from the Group for GRAPPA Composite Exercise (GRACE) study were used to develop cutoffs using a number of different approaches. Voting on choice of cutoff was undertaken at the 2013 GRAPPA Annual Meeting in Toronto, Ontario, Canada. RESULTS: After voting, results for cutoffs for low/high disease activity for the Psoriatic ArthritiS Disease Activity Score (PASDAS), GRAppa Composite scorE (GRACE index), and Composite Psoriatic Disease Activity Index (CPDAI), respectively, were 3.2/5.4, 2.3/4.7, and 4/8. The measurement error for each composite score was estimated at 0.8, 1, and 2 for PASDAS, GRACE, and CPDAI, respectively. CONCLUSION: Response criteria for the new composite indices have been developed. These now require further validation and testing in other datasets.
Authors: Anna Moverley; Laura Coates; Helena Marzo-Ortega; Robin Waxman; David Torgerson; Kim Cocks; Judith Watson; Philip S Helliwell Journal: Clin Rheumatol Date: 2015-02-03 Impact factor: 2.980
Authors: Burkhard F Leeb; Pia M Haindl; Hans-Peter Brezinschek; Harsono T H Mai; Christoph Deutsch; Bernhard Rintelen Journal: BMC Musculoskelet Disord Date: 2015-04-01 Impact factor: 2.362