Literature DB >> 24882401

Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases.

Tomoharu Kuboyama1, Chihiro Tohda, Katsuko Komatsu.   

Abstract

Neurodegenerative diseases commonly induce irreversible destruction of central nervous system (CNS) neuronal networks, resulting in permanent functional impairments. Effective medications against neurodegenerative diseases are currently lacking. Ashwagandha (roots of Withania somnifera Dunal) is used in traditional Indian medicine (Ayurveda) for general debility, consumption, nervous exhaustion, insomnia, and loss of memory. In this review, we summarize various effects and mechanisms of Ashwagandha extracts and related compounds on in vitro and in vivo models of neurodegenerative diseases such as Alzheimer's disease and spinal cord injury.

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Year:  2014        PMID： 24882401     DOI： 10.1248/bpb.b14-00022

Source DB:  PubMed          Journal:  Biol Pharm Bull        ISSN： 0918-6158            Impact factor:   2.233


  28 in total

Review 1.  Neuroprotection with Bacopa monnieri-A review of experimental evidence.

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Journal:  Mol Biol Rep       Date:  2021-03-06       Impact factor: 2.316

Review 2.  Role of Natural Compounds and Target Enzymes in the Treatment of Alzheimer's Disease.

Authors:  Shanshan Wang; Xianbo Kong; Zhangjing Chen; Guopin Wang; Juan Zhang; Jing Wang
Journal:  Molecules       Date:  2022-06-29       Impact factor: 4.927

3.  Withania somnifera and Its Withanolides Attenuate Oxidative and Inflammatory Responses and Up-Regulate Antioxidant Responses in BV-2 Microglial Cells.

Authors:  Grace Y Sun; Runting Li; Jiankun Cui; Mark Hannink; Zezong Gu; Kevin L Fritsche; Dennis B Lubahn; Agnes Simonyi
Journal:  Neuromolecular Med       Date:  2016-05-21       Impact factor: 3.843

Review 4.  Pharmacologic overview of Withania somnifera, the Indian Ginseng.

Authors:  Nawab John Dar; Abid Hamid; Muzamil Ahmad
Journal:  Cell Mol Life Sci       Date:  2015-08-26       Impact factor: 9.261

5.  Withania somnifera root powder protects againist post-traumatic stress disorder-induced memory impairment.

Authors:  Karem H Alzoubi; Arwa S Al Hilo; Qosay A Al-Balas; Khalid El-Salem; Tamam El-Elimat; Feras Q Alali
Journal:  Mol Biol Rep       Date:  2019-06-19       Impact factor: 2.316

6.  Withaferin A Induces Heat Shock Response and Ameliorates Disease Progression in a Mouse Model of Huntington's Disease.

Authors:  Tripti Joshi; Vipendra Kumar; Elena V Kaznacheyeva; Nihar Ranjan Jana
Journal:  Mol Neurobiol       Date:  2021-04-26       Impact factor: 5.590

7.  Functional and Morphological Correlates in the Drosophila LRRK2 loss-of-function Model of Parkinson's Disease: Drug Effects of Withania somnifera (Dunal) Administration.

Authors:  Francescaelena De Rose; Roberto Marotta; Simone Poddighe; Giuseppe Talani; Tiziano Catelani; Maria Dolores Setzu; Paolo Solla; Francesco Marrosu; Enrico Sanna; Sanjay Kasture; Elio Acquas; Anna Liscia
Journal:  PLoS One       Date:  2016-01-04       Impact factor: 3.240

8.  Novel Methods to Generate Active Ingredients-Enriched Ashwagandha Leaves and Extracts.

Authors:  Sunil C Kaul; Yoshiyuki Ishida; Kazuya Tamura; Teruo Wada; Tomoko Iitsuka; Sukant Garg; Mijung Kim; Ran Gao; Shoichi Nakai; Youji Okamoto; Keiji Terao; Renu Wadhwa
Journal:  PLoS One       Date:  2016-12-09       Impact factor: 3.240

9.  Differential effects of phytotherapic preparations in the hSOD1 Drosophila melanogaster model of ALS.

Authors:  Francescaelena De Rose; Roberto Marotta; Giuseppe Talani; Tiziano Catelani; Paolo Solari; Simone Poddighe; Giuseppe Borghero; Francesco Marrosu; Enrico Sanna; Sanjay Kasture; Elio Acquas; Anna Liscia
Journal:  Sci Rep       Date:  2017-01-19       Impact factor: 4.379

Review 10.  Role of Withaferin A and Its Derivatives in the Management of Alzheimer's Disease: Recent Trends and Future Perspectives.

Authors:  Rajib Das; Abdur Rauf; Saima Akhter; Mohammad Nazmul Islam; Talha Bin Emran; Saikat Mitra; Ishaq N Khan; Mohammad S Mubarak
Journal:  Molecules       Date:  2021-06-17       Impact factor: 4.411
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