F Chatonnet1, F Flamant2, B Morte3. 1. Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, CNRS, INRA, École Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Lyon Cedex 07, France. 2. Institut de Génomique Fonctionnelle de Lyon, Université de Lyon, CNRS, INRA, École Normale Supérieure de Lyon, 46 allée d'Italie, 69364 Lyon Cedex 07, France. Electronic address: Frederic.flamant@ens-lyon.fr. 3. Instituto de Investigaciones Biomédicas, Center for Biomedical Research on Rare Diseases (Ciberer), Instituto de Salud Carlos III, Madrid, Spain.
Abstract
BACKGROUND: Thyroid hormone controls a number of developmental and physiological processes in the brain by directly acting on gene expression. Transcriptome analyses in rodent identified a number of thyroid hormone regulated genes in several brain areas at different stages. Genome wide analysis of chromatin occupancy in a neural cell line also identified a subset of genes which transcription is likely to be directly regulated by thyroid hormone receptors in neurons. However, the abundance of these data and apparent discrepancies between studies brought some confusion. RESULTS: We present here a meta-analysis of available data to identify recurrent themes in thyroid hormone action in brain cells. This provides a curated list of 734 regulated genes in rodent brain, and highlights a small number of likely direct target genes. Some of these genes are also regulated in amphibians during metamorphosis. This article is part of a Special Issue entitled: Nuclear receptors in animal development.
BACKGROUND: Thyroid hormone controls a number of developmental and physiological processes in the brain by directly acting on gene expression. Transcriptome analyses in rodent identified a number of thyroid hormone regulated genes in several brain areas at different stages. Genome wide analysis of chromatin occupancy in a neural cell line also identified a subset of genes which transcription is likely to be directly regulated by thyroid hormone receptors in neurons. However, the abundance of these data and apparent discrepancies between studies brought some confusion. RESULTS: We present here a meta-analysis of available data to identify recurrent themes in thyroid hormone action in brain cells. This provides a curated list of 734 regulated genes in rodent brain, and highlights a small number of likely direct target genes. Some of these genes are also regulated in amphibians during metamorphosis. This article is part of a Special Issue entitled: Nuclear receptors in animal development.
Authors: Teresa H Sanders; Joseph Weiss; Luke Hogewood; Lan Chen; Casey Paton; Rebekah L McMahan; J David Sweatt Journal: J Neurosci Date: 2019-02-25 Impact factor: 6.167
Authors: M Elena Martinez; Aldona Karaczyn; J Patrizia Stohn; William T Donnelly; Walburga Croteau; Robin P Peeters; Valerie A Galton; Douglas Forrest; Donald St Germain; Arturo Hernandez Journal: Endocrinology Date: 2016-01-04 Impact factor: 4.736
Authors: Yasuhiro Kyono; Arasakumar Subramani; Preeti Ramadoss; Anthony N Hollenberg; Ronald M Bonett; Robert J Denver Journal: Endocrinology Date: 2016-07-07 Impact factor: 4.736