| Literature DB >> 24882150 |
Fabio Morandi1, Nathalie Rouas-Freiss2, Vito Pistoia3.
Abstract
HLA-G is an immunosuppressive molecule, that impairs the function of different immune cell populations, both in physiological and pathological conditions. Here, we have analyzed data obtained by our group and others regarding sHLA-G concentration in plasma from patients with different diseases. Next, we have summarized novel data regarding the impairment of chemotaxis of different immune effector cells mediated by sHLA-G. Finally, we have discussed the impact of this function on the immune response during cancer, viral infection, autoimmunity, and on B cell differentiation in secondary lymphoid organs. In conclusion, we have delineated a role of sHLA-G in the control of chemotaxis of immune effector cells, that may be relevant to modulate immune responses in different settings.Entities:
Keywords: Chemokine receptors; Chemotaxis; HLA-G
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Year: 2014 PMID： 24882150 DOI： 10.1016/j.cytogfr.2014.04.004
Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN： 1359-6101 Impact factor: 7.638