OBJECTIVE: To examine the effects of classification on treatment in major depressive disorder (MDD). METHOD: This is a narrative review. RESULTS: MDD is a highly heterogeneous category, leading to problems in classification and in specificity of treatment. Current models classify all depressions within a single category. However, the construct of MDD obscures important differences between severe disorders that require pharmacotherapy, and mild-to-moderate disorders that can respond to psychotherapy or remit spontaneously. Patients with mild-to-moderate MDD are being treated with routine or overly aggressive pharmacotherapy. CONCLUSIONS: The current classification fails to address the heterogeneity of depression, leading to mistreatment.
OBJECTIVE: To examine the effects of classification on treatment in major depressive disorder (MDD). METHOD: This is a narrative review. RESULTS:MDD is a highly heterogeneous category, leading to problems in classification and in specificity of treatment. Current models classify all depressions within a single category. However, the construct of MDD obscures important differences between severe disorders that require pharmacotherapy, and mild-to-moderate disorders that can respond to psychotherapy or remit spontaneously. Patients with mild-to-moderate MDD are being treated with routine or overly aggressive pharmacotherapy. CONCLUSIONS: The current classification fails to address the heterogeneity of depression, leading to mistreatment.
Authors: Jay C Fournier; Robert J DeRubeis; Steven D Hollon; Sona Dimidjian; Jay D Amsterdam; Richard C Shelton; Jan Fawcett Journal: JAMA Date: 2010-01-06 Impact factor: 56.272
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Authors: A John Rush; Madhukar H Trivedi; Stephen R Wisniewski; Jonathan W Stewart; Andrew A Nierenberg; Michael E Thase; Louise Ritz; Melanie M Biggs; Diane Warden; James F Luther; Kathy Shores-Wilson; George Niederehe; Maurizio Fava Journal: N Engl J Med Date: 2006-03-23 Impact factor: 91.245
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Authors: Aurélie M Lasserre; Sameer Imtiaz; Michael Roerecke; Markus Heilig; Charlotte Probst; Jürgen Rehm Journal: J Affect Disord Date: 2022-01-02 Impact factor: 4.839