Literature DB >> 2488106

Controlling cardiac arrhythmias: to delay conduction or to prolong refractoriness.

B N Singh1.   

Abstract

Recent data with encainide and flecainide (CAST study) question the benefit of reducing premature ventricular contractions in survivors of myocardial infarction. Proarrhythmic mechanisms might include excessive slowing of conduction. In patients with supraventricular tachycardias, proarrhythmic effects of Class 1c agents are very uncommon.

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Year:  1989        PMID： 2488106     DOI： 10.1007/bf01857618

Source DB:  PubMed          Journal:  Cardiovasc Drugs Ther        ISSN： 0920-3206            Impact factor:   3.727


  11 in total

1.  Control of cardiac arrhythmias by selective lengthening of repolarization: theoretic considerations and clinical observations.

Authors:  B N Singh; K Nademanee
Journal:  Am Heart J       Date:  1985-02       Impact factor: 4.749

2.  When is QT prolongation antiarrhythmic and when is it proarrhythmic?

Authors:  B N Singh
Journal:  Am J Cardiol       Date:  1989-04-01       Impact factor: 2.778

Review 3.  Ionic mechanisms in heart muscle in relation to the genesis and the pharmacological control of cardiac arrhythmias.

Authors:  O Hauswirth; B N Singh
Journal:  Pharmacol Rev       Date:  1978-03       Impact factor: 25.468

4.  Kinetics of onset of rate-dependent effects of Class I antiarrhythmic drugs are important in determining their effects on refractoriness in guinea-pig ventricle, and provide a theoretical basis for their subclassification.

Authors:  T J Campbell
Journal:  Cardiovasc Res       Date:  1983-06       Impact factor: 10.787

Review 5.  Encainide.

Authors:  M J Antonaccio; A W Gomoll; J E Byrne
Journal:  Cardiovasc Drugs Ther       Date:  1989-10       Impact factor: 3.727

6.  The Cardiac Arrhythmia Pilot Study. The CAPS investigators.

Authors: 
Journal:  Am J Cardiol       Date:  1986-01-01       Impact factor: 2.778

7.  Treatment of life-threatening ventricular tachycardia with encainide hydrochloride in patients with left ventricular dysfunction. The Encainide-Ventricular Tachycardia Study Group.

Authors: 
Journal:  Am J Cardiol       Date:  1988-09-15       Impact factor: 2.778

8.  The effect of amiodarone, a new anti-anginal drug, on cardiac muscle.

Authors:  B N Singh; E M Vaughan Williams
Journal:  Br J Pharmacol       Date:  1970-08       Impact factor: 8.739

9.  Pharmacologic conversion and suppression of experimental canine atrial flutter: differing effects of d-sotalol, quinidine, and lidocaine and significance of changes in refractoriness and conduction.

Authors:  G K Feld; N Venkatesh; B N Singh
Journal:  Circulation       Date:  1986-07       Impact factor: 29.690

10.  Effects of encainide, flecainide, imipramine and moricizine on ventricular arrhythmias during the year after acute myocardial infarction: the CAPS.

Authors: 
Journal:  Am J Cardiol       Date:  1988-03-01       Impact factor: 2.778
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  1 in total

1.  Acute effects of amiodarone on membrane properties, refractoriness, and conduction in guinea pig papillary muscles.

Authors:  T Maruyama; L C Richardson; W Sun; J J McCarthy; L S Gettes
Journal:  Heart Vessels       Date:  1995       Impact factor: 2.037
  1 in total

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