BACKGROUND: The role of genetic factors in colorectal cancer pathogenesis is widely accepted. Polymorphisms are actually thought to play a role in the unexplained colorectal cancer (CRC) susceptibility. There is conflicting data regarding the role of the transforming growth factor beta receptor 1 polymorphism 6A (TGFBR1*6A) in the increased incidence of CRC. PURPOSE: Our aim is to test the association between this polymorphism and sporadic/familial CRC in the Lebanese population paying attention to lead time bias in the control group. This is a case-control study conducted in two Lebanese hospital centers. MATERIALS AND METHODS: Cases were diagnosed with CRC during the period of 1 year prior to the study. Controls were healthy subjects aged >50 years with a history of normal colonoscopy during the period of 5 years prior to the beginning of the study. A total of 96 cases (57 sporadic/39 familial) and 97 controls were genotyped. The odds ratios for 6A carrier status was statistically significant for sporadic CRC, odds ratio (OR) = 2.314 (95 % confidence interval (CI) 1.030-5.195) but not for familial CRC. RESULTS: No association was found between 6A carrier status and mean age at diagnosis of CRC. This is the first article in the literature to evaluate the association between 6A polymorphism and total, sporadic, and familial CRC in a single study with reduction of bias in the control group. Results are in conjunction with other studies and meta-analysis.
BACKGROUND: The role of genetic factors in colorectal cancer pathogenesis is widely accepted. Polymorphisms are actually thought to play a role in the unexplained colorectal cancer (CRC) susceptibility. There is conflicting data regarding the role of the transforming growth factor beta receptor 1 polymorphism 6A (TGFBR1*6A) in the increased incidence of CRC. PURPOSE: Our aim is to test the association between this polymorphism and sporadic/familial CRC in the Lebanese population paying attention to lead time bias in the control group. This is a case-control study conducted in two Lebanese hospital centers. MATERIALS AND METHODS: Cases were diagnosed with CRC during the period of 1 year prior to the study. Controls were healthy subjects aged >50 years with a history of normal colonoscopy during the period of 5 years prior to the beginning of the study. A total of 96 cases (57 sporadic/39 familial) and 97 controls were genotyped. The odds ratios for 6A carrier status was statistically significant for sporadic CRC, odds ratio (OR) = 2.314 (95 % confidence interval (CI) 1.030-5.195) but not for familial CRC. RESULTS: No association was found between 6A carrier status and mean age at diagnosis of CRC. This is the first article in the literature to evaluate the association between 6A polymorphism and total, sporadic, and familial CRC in a single study with reduction of bias in the control group. Results are in conjunction with other studies and meta-analysis.
Authors: Johanna Skoglund; Bo Song; Johan Dalén; Stefan Dedorson; David Edler; Fredrik Hjern; Jörn Holm; Claes Lenander; Ulrik Lindforss; Nils Lundqvist; Hans Olivecrona; Louise Olsson; Lars Påhlman; Jörgen Rutegård; Kennet Smedh; Anders Törnqvist; Richard S Houlston; Annika Lindblom Journal: Clin Cancer Res Date: 2007-06-15 Impact factor: 12.531
Authors: A M Stefanovska; G D Efremov; A J Dimovski; D Jasar; G Zografski; T Josifovski; M Panovski; R Jankova; M Spiroski Journal: Cancer Res Date: 2001-11-15 Impact factor: 12.701
Authors: B Pasche; P Kolachana; K Nafa; J Satagopan; Y G Chen; R S Lo; D Brener; D Yang; L Kirstein; C Oddoux; H Ostrer; P Vineis; L Varesco; S Jhanwar; L Luzzatto; J Massagué; K Offit Journal: Cancer Res Date: 1999-11-15 Impact factor: 12.701
Authors: Virginia G Kaklamani; Nanjiang Hou; Yiansong Bian; Jennifer Reich; Kenneth Offit; Loren S Michel; W S Rubinstein; Alfred Rademaker; Boris Pasche Journal: J Clin Oncol Date: 2003-09-01 Impact factor: 44.544
Authors: Tony Ibrahim; Claude Saer-Ghorra; Vivane Trak-Smayra; Samah Nadiri; Charbel Yazbeck; Maria Baz; Joseph G Kattan Journal: Ann Saudi Med Date: 2018 Jul-Aug Impact factor: 1.526