P Z Akilimali1, P B Mutombo2, P K Kayembe2, D K Kaba2, M A Mapatano2. 1. Département de nutrition, école de santé publique, université de Kinshasa, 17, Kananga Street, PB 11850, Kinshasa I, République démocratique du Congo. Electronic address: dakza2001@yahoo.fr. 2. Département de nutrition, école de santé publique, université de Kinshasa, 17, Kananga Street, PB 11850, Kinshasa I, République démocratique du Congo.
Abstract
BACKGROUND: The study aimed to identify factors associated with the survival of patients receiving antiretroviral therapy. METHODS: A historic cohort of HIV patients from two major hospitals in Goma (Democratic Republic of Congo) was followed from 2004 to 2012. The Kaplan-Meier method was used to describe the probability of survival as a function of time since inclusion into the cohort. The log-rank test was used to compare survival curves based on determinants. The Cox regression model identified the determinants of survival since treatment induction. RESULTS: The median follow-up time was 3.56 years (IQR=2.22-5.39). The mortality rate was 40 deaths per 1000 person-years. Male gender (RR: 2.56; 95 %CI 1.66-4.83), advanced clinical stage (RR: 2.12; 95 %CI 1.15-3.90), low CD4 count (CD4 < 50) (RR: 2.05; 95 %CI : 1.22-3.45), anemia (RR: 3.95; 95 %CI 2.60-6.01), chemoprophylaxis with cotrimoxazole (RR: 4.29, 95 % CI 2.69-6.86) and period of treatment initiation (2010-2011) (RR: 3.34; 95 %CI 1.24-8.98) were statistically associated with short survival. CONCLUSION: Initiation of treatment at an early stage of the disease with use of less toxic molecules and an increased surveillance especially of male patients are recommended to reduce mortality.
BACKGROUND: The study aimed to identify factors associated with the survival of patients receiving antiretroviral therapy. METHODS: A historic cohort of HIVpatients from two major hospitals in Goma (Democratic Republic of Congo) was followed from 2004 to 2012. The Kaplan-Meier method was used to describe the probability of survival as a function of time since inclusion into the cohort. The log-rank test was used to compare survival curves based on determinants. The Cox regression model identified the determinants of survival since treatment induction. RESULTS: The median follow-up time was 3.56 years (IQR=2.22-5.39). The mortality rate was 40 deaths per 1000 person-years. Male gender (RR: 2.56; 95 %CI 1.66-4.83), advanced clinical stage (RR: 2.12; 95 %CI 1.15-3.90), low CD4 count (CD4 < 50) (RR: 2.05; 95 %CI : 1.22-3.45), anemia (RR: 3.95; 95 %CI 2.60-6.01), chemoprophylaxis with cotrimoxazole (RR: 4.29, 95 % CI 2.69-6.86) and period of treatment initiation (2010-2011) (RR: 3.34; 95 %CI 1.24-8.98) were statistically associated with short survival. CONCLUSION: Initiation of treatment at an early stage of the disease with use of less toxic molecules and an increased surveillance especially of male patients are recommended to reduce mortality.
Authors: Pierre Zalagile Akilimali; Espérance Kashala-Abotnes; Patou Masika Musumari; Patrick Kalambayi Kayembe; Thorkild Tylleskar; Mala Ali Mapatano Journal: PLoS One Date: 2015-10-16 Impact factor: 3.240
Authors: Roger T Buju; Pierre Z Akilimali; Nguyen-Toan Tran; Erick N Kamangu; Gauthier K Mesia; Jean Marie N Kayembe; Hippolyte N Situakibanza Journal: Int J Environ Res Public Health Date: 2022-08-17 Impact factor: 4.614