| Literature DB >> 24880214 |
Jae Geun Kim1, Shigetomo Suyama1, Marco Koch2, Sungho Jin1, Pilar Argente-Arizon3, Jesús Argente3, Zhong-Wu Liu1, Marcelo R Zimmer1, Jin Kwon Jeong4, Klara Szigeti-Buck1, Yuanqing Gao5, Cristina Garcia-Caceres5, Chun-Xia Yi5, Natalina Salmaso6, Flora M Vaccarino7, Julie Chowen3, Sabrina Diano8, Marcelo O Dietrich1, Matthias H Tschöp5, Tamas L Horvath8.
Abstract
We found that leptin receptors were expressed in hypothalamic astrocytes and that their conditional deletion led to altered glial morphology and synaptic inputs onto hypothalamic neurons involved in feeding control. Leptin-regulated feeding was diminished, whereas feeding after fasting or ghrelin administration was elevated in mice with astrocyte-specific leptin receptor deficiency. These data reveal an active role of glial cells in hypothalamic synaptic remodeling and control of feeding by leptin.Entities:
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Year: 2014 PMID： 24880214 PMCID： PMC4113214 DOI： 10.1038/nn.3725
Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 28.771