Literature DB >> 24879739

A non-fatal intoxication with a high-dose sodium nitrate.

Dorien Joosen1, Leo Stolk2, Ronald Henry1.   

Abstract

A 67-year-old man accidentally ingested 75 g of sodium nitrate. He had instant gastrointestinal symptoms. On physical examination, he was respiratorily and haemodynamically stable and there were no signs of central or peripheral cyanosis. Repeated methaemoglobin levels were normal and he made an uneventful recovery. Sodium nitrate intoxication is rare. Serious effects can occur, mainly through formation of nitrite and nitric oxide, which can cause methaemoglobinaemia and vasodilation. Even if the presenting symptoms are mild, it is important to remain cautious since more serious symptoms can occur later. Monitoring of respiratory and haemodynamic status and repeated blood gas analysis in order to detect methaemoglobinaemia are recommended. 2014 BMJ Publishing Group Ltd.

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Year:  2014        PMID: 24879739      PMCID: PMC4039755          DOI: 10.1136/bcr-2014-204825

Source DB:  PubMed          Journal:  BMJ Case Rep        ISSN: 1757-790X


  7 in total

1.  The effect of dietary nitrate on salivary, plasma, and urinary nitrate metabolism in humans.

Authors:  Ananth S Pannala; Ali R Mani; Jeremy P E Spencer; Vernon Skinner; K Richard Bruckdorfer; Kevin P Moore; Catherine A Rice-Evans
Journal:  Free Radic Biol Med       Date:  2003-03-01       Impact factor: 7.376

2.  Fatal methaemoglobinaemia induced by self-poisoning with sodium nitrite.

Authors:  Martyn Harvey; Grant Cave; Giles Chanwai
Journal:  Emerg Med Australas       Date:  2010-10       Impact factor: 2.151

3.  Acute nitrate poisoning: a report of 80 cases.

Authors:  L Gao; Y S Guo
Journal:  Am J Emerg Med       Date:  1991-03       Impact factor: 2.469

4.  A case of fatal methemoglobinemia of unknown origin but presumably due to ingestion of nitrate.

Authors:  T Saito; S Takeichi; M Osawa; N Yukawa; X L Huang
Journal:  Int J Legal Med       Date:  2000       Impact factor: 2.686

5.  Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO.

Authors:  Vikas Kapil; Alexandra B Milsom; Michael Okorie; Sheiva Maleki-Toyserkani; Farihah Akram; Farkhanda Rehman; Shah Arghandawi; Vanessa Pearl; Nigel Benjamin; Stavros Loukogeorgakis; Raymond Macallister; Adrian J Hobbs; Andrew J Webb; Amrita Ahluwalia
Journal:  Hypertension       Date:  2010-06-28       Impact factor: 10.190

6.  Accidental acute fatal sodium nitrite poisoning.

Authors:  S Gautami; R N Rao; T C Raghuram; S Rajagopalan; R V Bhat
Journal:  J Toxicol Clin Toxicol       Date:  1995

7.  The oral bioavailability of nitrate from nitrate-rich vegetables in humans.

Authors:  Agnes G van Velzen; Adrienne J A M Sips; Ronald C Schothorst; Annette C Lambers; Jan Meulenbelt
Journal:  Toxicol Lett       Date:  2008-08-03       Impact factor: 4.372

  7 in total
  1 in total

1.  Survival after self-poisoning with sodium nitrite: A case report.

Authors:  Adiba M Matin; Eric T Boie; Gregory P Moore
Journal:  J Am Coll Emerg Physicians Open       Date:  2022-03-17
  1 in total

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