OBJECTIVE: Bent spine syndrome (BSS), defined as an abnormal forward flexion of the trunk resolving in supine position, is usually related to parkinsonism, but can also be encountered in myopathies. This study evaluates whole-body muscle MRI (WB-mMRI) as a tool for detecting underlying myopathy in non-extrapyramidal BSS. MATERIALS AND METHODS: Forty-three patients (90 % women; 53-86 years old) with a non-extrapyramidal BSS were prospectively included. All underwent a 1.5-T WB-mMRI and a nerve conduction study. Muscle biopsy was performed if a myopathy could not be eliminated based on clinical examination and all tests. Systematic MRI interpretation focused on peripheral and axial muscle injury; spinal posture and incidental findings were also reported. RESULTS: WB-mMRI was completed for all patients, with 13 muscle biopsies ultimately needed and myopathy revealed as the final etiological diagnosis in five cases (12 %). All biopsy-proven myopathies were detected by the WB-mMRI. Relevant incidental MRI findings were made in seven patients. CONCLUSIONS: This study supports WB-mMRI as a sensitive and feasible tool for detecting myopathy in BSS patients. Associated with electroneuromyography, it can better indicate when a muscle biopsy is needed and guide it when required. Rigorous radiological interpretation is mandatory, so as not to miss incidental findings of clinical consequence.
OBJECTIVE: Bent spine syndrome (BSS), defined as an abnormal forward flexion of the trunk resolving in supine position, is usually related to parkinsonism, but can also be encountered in myopathies. This study evaluates whole-body muscle MRI (WB-mMRI) as a tool for detecting underlying myopathy in non-extrapyramidal BSS. MATERIALS AND METHODS: Forty-three patients (90 % women; 53-86 years old) with a non-extrapyramidal BSS were prospectively included. All underwent a 1.5-T WB-mMRI and a nerve conduction study. Muscle biopsy was performed if a myopathy could not be eliminated based on clinical examination and all tests. Systematic MRI interpretation focused on peripheral and axial muscle injury; spinal posture and incidental findings were also reported. RESULTS: WB-mMRI was completed for all patients, with 13 muscle biopsies ultimately needed and myopathy revealed as the final etiological diagnosis in five cases (12 %). All biopsy-proven myopathies were detected by the WB-mMRI. Relevant incidental MRI findings were made in seven patients. CONCLUSIONS: This study supports WB-mMRI as a sensitive and feasible tool for detecting myopathy in BSSpatients. Associated with electroneuromyography, it can better indicate when a muscle biopsy is needed and guide it when required. Rigorous radiological interpretation is mandatory, so as not to miss incidental findings of clinical consequence.
Authors: Rachel D Susman; Susana Quijano-Roy; Nan Yang; Richard Webster; Nigel F Clarke; Jim Dowling; Marina Kennerson; Garth Nicholson; Valerie Biancalana; Biljana Ilkovski; Kevin M Flanigan; Susan Arbuckle; Chandra Malladi; Phillip Robinson; Steven Vucic; Michèle Mayer; Norma B Romero; Jon Andoni Urtizberea; Federico García-Bragado; Pascale Guicheney; Marc Bitoun; Robert-Yves Carlier; Kathryn N North Journal: Neuromuscul Disord Date: 2010-03-12 Impact factor: 4.296
Authors: V Delcey; E Hachulla; U Michon-Pasturel; V Queyrel; P Y Hatron; N Boutry; V Lemaitre; P Vanhille; J Serratrice; P Disdier; V Juhan; B Devulder; A Thévenon Journal: Rev Med Interne Date: 2002-02 Impact factor: 0.728
Authors: A Pichiecchio; G U Poloni; S Ravaglia; M Ponzio; G Germani; D Maranzana; A Costa; A Repetto; E Tavazzi; C Danesino; A Moglia; S Bastianello Journal: Muscle Nerve Date: 2009-07 Impact factor: 3.217
Authors: Sarah Finlayson; Jasper M Morrow; Pedro M Rodriguez Cruz; Christopher D J Sinclair; Arne Fischmann; John S Thornton; Steve Knight; Ray Norbury; Mel White; Michal Al-Hajjar; Nicola Carboni; Sandeep Jayawant; Stephanie A Robb; Tarek A Yousry; David Beeson; Jacqueline Palace Journal: Muscle Nerve Date: 2016-02-22 Impact factor: 3.217