Lei Shao1, Liang Xu2, Wen Bin Wei3, Chang Xi Chen2, Kui Fang Du1, Xiao Peng Li4, Ming Yang4, Ya Xing Wang2, Qi Sheng You2, Jost B Jonas5. 1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 2. Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 3. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address: wenbing_wei@yahoo.com.cn. 4. Beijing Tongren Hospital, Capital Medical University, Beijing, China. 5. Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China; Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University, Heidelberg, Germany.
Abstract
PURPOSE: To examine the association between best corrected visual acuity (BCVA) and subfoveal choroidal thickness. DESIGN: Population-based study. METHODS: The Beijing Eye Study 2011 included 3468 subjects with ages of 50+ years. The participants underwent an ophthalmologic examination including spectral-domain optical coherence tomography with enhanced depth imaging for measurement of choroidal thickness. BCVA was measured as logarithm of the minimal angle of resolution. RESULTS: Of the 3468 participants, choroidal measurements were available for 3233 (93.2%) subjects. In multivariate analysis, better BCVA was significantly associated with thicker subfoveal choroid (P < 0.001) in general and a subfoveal choroid thicker than 30 μm (P < 0.001) in particular, after adjusting for younger age (P < 0.001), higher level of education (P < 0.001), taller body stature (P < 0.001), higher body mass index (P = 0.005), absence of glaucoma (P = 0.001), absence of diabetic retinopathy (P < 0.001), absence of late-stage age-related macular degeneration (P < 0.001), and axial length shorter than 26.0 mm (P < 0.001) (correlation coefficient r:0.56). If eyes with glaucoma, diabetic retinopathy, late-stage age-related macular degeneration or myopic retinopathy were excluded, better BCVA was still significantly associated with thicker subfoveal choroid (P < 0.001) and subfoveal choroid thicker than 30 μm (P < 0.001) in multivariate analysis. In a reverse manner, thicker subfoveal choroid was associated with better BCVA (P < 0.001) after adjusting for younger age (P < 0.001), male gender (P < 0.001), longer axial length (P < 0.001), and higher corneal curvature radius (P < 0.001). CONCLUSIONS: Better visual acuity is strongly associated with thicker subfoveal choroid independent of additional factors, such as age, axial length, education level, and major ocular diseases.
PURPOSE: To examine the association between best corrected visual acuity (BCVA) and subfoveal choroidal thickness. DESIGN: Population-based study. METHODS: The Beijing Eye Study 2011 included 3468 subjects with ages of 50+ years. The participants underwent an ophthalmologic examination including spectral-domain optical coherence tomography with enhanced depth imaging for measurement of choroidal thickness. BCVA was measured as logarithm of the minimal angle of resolution. RESULTS: Of the 3468 participants, choroidal measurements were available for 3233 (93.2%) subjects. In multivariate analysis, better BCVA was significantly associated with thicker subfoveal choroid (P < 0.001) in general and a subfoveal choroid thicker than 30 μm (P < 0.001) in particular, after adjusting for younger age (P < 0.001), higher level of education (P < 0.001), taller body stature (P < 0.001), higher body mass index (P = 0.005), absence of glaucoma (P = 0.001), absence of diabetic retinopathy (P < 0.001), absence of late-stage age-related macular degeneration (P < 0.001), and axial length shorter than 26.0 mm (P < 0.001) (correlation coefficient r:0.56). If eyes with glaucoma, diabetic retinopathy, late-stage age-related macular degeneration or myopic retinopathy were excluded, better BCVA was still significantly associated with thicker subfoveal choroid (P < 0.001) and subfoveal choroid thicker than 30 μm (P < 0.001) in multivariate analysis. In a reverse manner, thicker subfoveal choroid was associated with better BCVA (P < 0.001) after adjusting for younger age (P < 0.001), male gender (P < 0.001), longer axial length (P < 0.001), and higher corneal curvature radius (P < 0.001). CONCLUSIONS: Better visual acuity is strongly associated with thicker subfoveal choroid independent of additional factors, such as age, axial length, education level, and major ocular diseases.
Authors: Jie Lu; Hao Zhou; Yingying Shi; James Choe; Mengxi Shen; Liang Wang; Kelly Chen; Qinqin Zhang; William J Feuer; Giovanni Gregori; Philip J Rosenfeld; Ruikang K Wang Journal: Quant Imaging Med Surg Date: 2022-01
Authors: Rahul Arvo Jonas; Ya Xing Wang; Hua Yang; Jian Jun Li; Liang Xu; Songhomitra Panda-Jonas; Jost Bruno Jonas Journal: PLoS One Date: 2015-09-21 Impact factor: 3.240
Authors: Hai Xia Bai; Ying Mao; Ling Shen; Xiao Lin Xu; Fei Gao; Zhi Bao Zhang; Bin Li; Jost B Jonas Journal: PLoS One Date: 2017-08-02 Impact factor: 3.240