BACKGROUND: Human obesity is associated with a proinflammatory state and an elevated level of mediators, such as C-reactive protein (CRP). OBJECTIVES: To establish CRP levels as baseline preoperative values and then at 6 months after bariatric surgery, as well as to determine the changes in weight, body mass index (BMI), leukocytes, and glycemia. MATERIALS AND METHODS: An observational, analytical, retrospective, longitudinal, and open study was conducted. Serum CRP values were measured in 36 adults presenting with morbid obesity, and their baseline relation to weight, BMI, leukocytes, and glycemia was determined; the relation to the same parameters was established again, 6 months after bariatric surgery. RESULTS: The mean and standard deviation of preoperative and postoperative CRP (mg/L) was 1.15±0.86 and 0.34±0.28, respectively with p<0.0001; weight (kg) 112.10±22.91 and 84.82±17.11, p=0.0443; BMI (kg/m(2)) 42.48±5.97 and 32.2±4.79, p=0.0988; glucose (mg/dL) 100.58±17.82 and 87.11±8.49, p<0.0001, and leukocytes (× 10(3)/mm(3)) 8.62±1.69 and 6.99±1.56, p=0.3192. Baseline CRP only correlated with weight and BMI (p=0.047 and p=0.027 respectively) and there was no correlation between postoperative CRP and the evaluated parameters. CONCLUSIONS: Preoperative CRP had a significant lineal relation to weight and body mass index. Patients who underwent bariatric surgery had a significant decrease in CRP, weight, and fasting glucose at 6 months after surgery.
BACKGROUND:Humanobesity is associated with a proinflammatory state and an elevated level of mediators, such as C-reactive protein (CRP). OBJECTIVES: To establish CRP levels as baseline preoperative values and then at 6 months after bariatric surgery, as well as to determine the changes in weight, body mass index (BMI), leukocytes, and glycemia. MATERIALS AND METHODS: An observational, analytical, retrospective, longitudinal, and open study was conducted. Serum CRP values were measured in 36 adults presenting with morbid obesity, and their baseline relation to weight, BMI, leukocytes, and glycemia was determined; the relation to the same parameters was established again, 6 months after bariatric surgery. RESULTS: The mean and standard deviation of preoperative and postoperative CRP (mg/L) was 1.15±0.86 and 0.34±0.28, respectively with p<0.0001; weight (kg) 112.10±22.91 and 84.82±17.11, p=0.0443; BMI (kg/m(2)) 42.48±5.97 and 32.2±4.79, p=0.0988; glucose (mg/dL) 100.58±17.82 and 87.11±8.49, p<0.0001, and leukocytes (× 10(3)/mm(3)) 8.62±1.69 and 6.99±1.56, p=0.3192. Baseline CRP only correlated with weight and BMI (p=0.047 and p=0.027 respectively) and there was no correlation between postoperative CRP and the evaluated parameters. CONCLUSIONS: Preoperative CRP had a significant lineal relation to weight and body mass index. Patients who underwent bariatric surgery had a significant decrease in CRP, weight, and fasting glucose at 6 months after surgery.
Authors: Jennifer Wilbrink; Nienke Bernards; Zlatan Mujagic; Mark van Avesaat; Kirsten Pijls; Tim Klaassen; Hans van Eijk; Simon Nienhuijs; Arnold Stronkhorst; Ellen Wilms; Freddy Troost; Ad Masclee Journal: Int J Obes (Lond) Date: 2019-12-09 Impact factor: 5.095
Authors: Ahmed Salman; Mohamed Salman; Mohamed D Sarhan; Karim Maurice; Mohamed Tag El-Din; Ahmed Youssef; Reham Ahmed; Tarek Abouelregal; Hossam El-Din Shaaban; Ghada M K GabAllah; Mahmoud Gouda Omar Journal: Int J Gen Med Date: 2021-03-10
Authors: Monika H E Christensen; Dag J Fadnes; Therese H Røst; Eva R Pedersen; John R Andersen; Villy Våge; Arve Ulvik; Øivind Midttun; Per M Ueland; Ottar K Nygård; Gunnar Mellgren Journal: PLoS One Date: 2018-02-05 Impact factor: 3.240
Authors: José Romeo Villarreal-Calderón; Ricardo X Cuéllar; Martín R Ramos-González; Nestor Rubio-Infante; Elena C Castillo; Leticia Elizondo-Montemayor; Gerardo García-Rivas Journal: Oxid Med Cell Longev Date: 2019-12-06 Impact factor: 6.543