C Bosc1, M Clement2, A Deroux3, A Mammar4, C Pison4, B Camara4. 1. Clinique universitaire de pneumologie, hôpital Albert-Michallon, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France. Electronic address: CBosc1@chu-grenoble.fr. 2. Service de pneumologie et d'oncologie thoracique, centre hospitalier de Chambéry, 73000 Chambéry, France. 3. Clinique universitaire de pneumologie, hôpital Albert-Michallon, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France; Service de pneumologie et d'oncologie thoracique, centre hospitalier de Chambéry, 73000 Chambéry, France. 4. Clinique universitaire de pneumologie, hôpital Albert-Michallon, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France.
Abstract
UNLABELLED: Severe pneumonia due to cytomegalovirus in chronic obstructive pulmonary disease. INTRODUCTION: We describe two cases of immunocompetent patients with chronic obstructive pulmonary disease (COPD) who developed severe cytomegalovirus (CMV) pneumonia. The clinical and radiological context and CMV replication in broncho-alveolar lavage suggested a diagnosis of CMV pneumonia. CASE HISTORIES: We report two cases in patients with moderate chronic obstructive pulmonary disease not treated with long-term steroid therapy who developed bilateral pneumonia with hypoxaemia. The only pathogen identified was CMV with replication of the virus in the broncho-alveolar lavage. Investigation failed to detect any associated immune deficiency. CONCLUSION: Severe cytomegalovirus pneumonia could be encouraged by the existence of chronic obstructive pulmonary disease due to local inflammatory changes.
UNLABELLED: Severe pneumonia due to cytomegalovirus in chronic obstructive pulmonary disease. INTRODUCTION: We describe two cases of immunocompetent patients with chronic obstructive pulmonary disease (COPD) who developed severe cytomegalovirus (CMV) pneumonia. The clinical and radiological context and CMV replication in broncho-alveolar lavage suggested a diagnosis of CMV pneumonia. CASE HISTORIES: We report two cases in patients with moderate chronic obstructive pulmonary disease not treated with long-term steroid therapy who developed bilateral pneumonia with hypoxaemia. The only pathogen identified was CMV with replication of the virus in the broncho-alveolar lavage. Investigation failed to detect any associated immune deficiency. CONCLUSION: Severe cytomegalovirus pneumonia could be encouraged by the existence of chronic obstructive pulmonary disease due to local inflammatory changes.