| Literature DB >> 24877715 |
Nayeema Akther1, Khursheed Andrabi2, Albeena Nissar3, Showkat Ganaie3, B K Chandan3, A P Gupta3, Manoj Khuswant3, Sarwat Sultana4, Abdul S Shawl5.
Abstract
The study was designed to evaluate the hepatoprotective activity of Iris spuria against paracetamol induced toxicity at two different doses 100 and 200 mg/kg. The extract showed significant protective activity (p>0.01) at both the doses in dose dependent manner. Administration of the plant extract restored the paracetamol induced elevated levels of serum marker and distorted hepatic tissue architecture. The lipid peroxides (LPO) and glutathione (GSH) levels were also restored towards normal in liver tissue significantly. The main chemical constituents of the extract identified by the liquid chromatography-tandem mass spectrometry (LC-ESI-MSMS) were found to be flavones and isoflavonoids. Tectoridin and iristectorigenin A were the principal compounds present in the methanolic extract of Iris spuria.Entities:
Keywords: Hepatoprotective; Iris spuria; Isoflavonoids; Paracetamol; Tectoridin
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Year: 2014 PMID： 24877715 DOI： 10.1016/j.phymed.2014.04.007
Source DB: PubMed Journal: Phytomedicine ISSN： 0944-7113 Impact factor: 5.340