Literature DB >> 24875755

The failure of genomics in biology.

Mark Viney1.   

Abstract

We live in the age of genomics and have discovered hundreds of thousands of genes of which we understand almost nothing: genomics has failed biology. We need to understand what genes do, something that we have stopped studying. Parasites are different from free-living species, and so they will have genes with novel functions, which we will only discover by studying this directly, not by doing genomics.
Copyright © 2014 Elsevier Ltd. All rights reserved.

Keywords:  genomics; knock-out; parasites

Mesh：

Year:  2014        PMID： 24875755     DOI： 10.1016/j.pt.2014.04.010

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  6 in total

1.  Genomics illuminates parasite biology.

Authors:  Bernardo J Foth; Thomas D Otto
Journal:  Nat Rev Microbiol       Date:  2014-11       Impact factor: 60.633

2.  Identification and evaluation of vaccine candidate antigens from the poultry red mite (Dermanyssus gallinae).

Authors:  Kathryn Bartley; Harry W Wright; John F Huntley; Erin D T Manson; Neil F Inglis; Kevin McLean; Mintu Nath; Yvonne Bartley; Alasdair J Nisbet
Journal:  Int J Parasitol       Date:  2015-08-19       Impact factor: 3.981

3.  Niche-specific gene expression in a parasitic nematode; increased expression of immunomodulators in Teladorsagia circumcincta larvae derived from host mucosa.

Authors:  Tom N McNeilly; David Frew; Stewart T G Burgess; Harry Wright; David J Bartley; Yvonne Bartley; Alasdair J Nisbet
Journal:  Sci Rep       Date:  2017-08-03       Impact factor: 4.379

Review 4.  How Can We Understand the Genomic Basis of Nematode Parasitism?

Authors:  Mark Viney
Journal:  Trends Parasitol       Date:  2017-03-06

5.  Goodbye genome paper, hello genome report: the increasing popularity of 'genome announcements' and their impact on science.

Authors:  David Roy Smith
Journal:  Brief Funct Genomics       Date:  2017-05-01       Impact factor: 4.241

6.  Rescue of degenerating neurons and cells by stem cell released molecules: using a physiological renormalization strategy.

Authors:  Greg Maguire; Lee Paler; Linda Green; Rosa Mella; Maria Valcarcel; Patricia Villace
Journal:  Physiol Rep       Date:  2019-05
  6 in total

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