Sarah A Milgrom1, Marisa A Kollmeier1, Nadeem R Abu-Rustum2, Roisin E O'Cearbhaill3, Richard R Barakat2, Kaled M Alektiar4. 1. Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. 2. Department of Surgery, Gynecology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. 3. Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. 4. Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. Electronic address: alektiak@mskcc.org.
Abstract
OBJECTIVE: Advanced endometrial cancer patients comprise a heterogeneous group. This study assessed the association of clinicopathological factors with relapse and death from endometrial cancer. METHODS: Eligible patients were treated for stage III (FIGO 2009) endometrial adenocarcinoma, had peritoneal cytology performed, and had no gross residual disease post-operatively. RESULTS: Of 192 patients, 59% were ≥60 years old, 48% had ≥50% myometrial invasion, 71% lymphovascular invasion, 25% cervical stromal invasion, 37% adnexal involvement, and 23% positive peritoneal cytology. High-grade histology (serous, clear cell, undifferentiated, or grade 3 endometrioid) was present in 45%. Pelvic lymphadenectomy was performed in 93% and para-aortic lymphadenectomy in 73%. Adjuvant chemotherapy and/or radiation therapy was administered to 93%. At a median follow-up of 42 months, the 5-year rate of relapse was 37% and of death from endometrial cancer was 30%. On multivariate analysis, both outcomes were associated with high-grade histology, positive peritoneal cytology, and deep myometrial invasion (p≤0.04). The cohort was divided into subgroups of patients with 0 (n=46), 1 (n=83), or ≥2 (n=63) of these high-risk characteristics. The 5-year relapse rate for patients with 0 risk factors was 13%, 1 risk factor was 27%, and ≥2 risk factors was 62% (p<0.001). The corresponding 5-year rates of death from endometrial cancer were 11%, 20%, and 56%, respectively (p<0.001). CONCLUSIONS: Stratification of stage III endometrial cancer according to high-grade histology, positive peritoneal cytology, and deep myometrial invasion is useful for prognostication and may grant insight into the optimal treatment for specific subgroups of patients.
OBJECTIVE: Advanced endometrial cancerpatients comprise a heterogeneous group. This study assessed the association of clinicopathological factors with relapse and death from endometrial cancer. METHODS: Eligible patients were treated for stage III (FIGO 2009) endometrial adenocarcinoma, had peritoneal cytology performed, and had no gross residual disease post-operatively. RESULTS: Of 192 patients, 59% were ≥60 years old, 48% had ≥50% myometrial invasion, 71% lymphovascular invasion, 25% cervical stromal invasion, 37% adnexal involvement, and 23% positive peritoneal cytology. High-grade histology (serous, clear cell, undifferentiated, or grade 3 endometrioid) was present in 45%. Pelvic lymphadenectomy was performed in 93% and para-aortic lymphadenectomy in 73%. Adjuvant chemotherapy and/or radiation therapy was administered to 93%. At a median follow-up of 42 months, the 5-year rate of relapse was 37% and of death from endometrial cancer was 30%. On multivariate analysis, both outcomes were associated with high-grade histology, positive peritoneal cytology, and deep myometrial invasion (p≤0.04). The cohort was divided into subgroups of patients with 0 (n=46), 1 (n=83), or ≥2 (n=63) of these high-risk characteristics. The 5-year relapse rate for patients with 0 risk factors was 13%, 1 risk factor was 27%, and ≥2 risk factors was 62% (p<0.001). The corresponding 5-year rates of death from endometrial cancer were 11%, 20%, and 56%, respectively (p<0.001). CONCLUSIONS: Stratification of stage III endometrial cancer according to high-grade histology, positive peritoneal cytology, and deep myometrial invasion is useful for prognostication and may grant insight into the optimal treatment for specific subgroups of patients.
Authors: Jennifer C Ho; Pamela K Allen; Anuja Jhingran; Shannon N Westin; Karen H Lu; Patricia J Eifel; Ann H Klopp Journal: Gynecol Oncol Date: 2015-07-17 Impact factor: 5.482
Authors: Song Xue; Shu Xiao-Hong; Sha Lin; Bian Jie; Wang Li-Li; Gu Jia-Yao; Shi Shun; Li Pei-Nan; Wu Mo-Li; Wang Qian; Chen Xiao-Yan; Kong Qing-You; Zhang Peng; Li Hong; Liu Jia Journal: Oncotarget Date: 2016-11-15