OBJECTIVE: To assess the prevalence of peripheral neuropathy in HIV infected children (>5 y) receiving stavudine-based combination anti-retroviral treatment (ART) for more than 3 mo in a cross-sectional study. METHODS: History, detailed neurological examination and nerve conduction studies were performed. RESULTS: Forty children [26 boys; median age - 11.75 y, Inter quartile range (IQR): 9-16 y] were enrolled. The median duration of ART was 43 mo [IQR: 18-69 mo]. The nerve conduction studies were abnormal in four children (10 %). Symptomatic distal sensory polyneuropathy was present in two children, asymptomatic distal sensory polyneuropathy and subclinical distal sensory polyneuropathy was present in one child each. CONCLUSIONS: Distal sensory polyneuropathy is a potential problem in children on stavudine based ART. Children on stavudine based ART need periodic clinical and electrophysiological screening for its early detection.
OBJECTIVE: To assess the prevalence of peripheral neuropathy in HIV infectedchildren (>5 y) receiving stavudine-based combination anti-retroviral treatment (ART) for more than 3 mo in a cross-sectional study. METHODS: History, detailed neurological examination and nerve conduction studies were performed. RESULTS: Forty children [26 boys; median age - 11.75 y, Inter quartile range (IQR): 9-16 y] were enrolled. The median duration of ART was 43 mo [IQR: 18-69 mo]. The nerve conduction studies were abnormal in four children (10 %). Symptomatic distal sensory polyneuropathy was present in two children, asymptomatic distal sensory polyneuropathy and subclinical distal sensory polyneuropathy was present in one child each. CONCLUSIONS: Distal sensory polyneuropathy is a potential problem in children on stavudine based ART. Children on stavudine based ART need periodic clinical and electrophysiological screening for its early detection.
Authors: G Famularo; S Moretti; S Marcellini; V Trinchieri; S Tzantzoglou; G Santini; A Longo; C De Simone Journal: AIDS Date: 1997-02 Impact factor: 4.177
Authors: F J Palella; K M Delaney; A C Moorman; M O Loveless; J Fuhrer; G A Satten; D J Aschman; S D Holmberg Journal: N Engl J Med Date: 1998-03-26 Impact factor: 91.245
Authors: Scott R Evans; Ronald J Ellis; Huichao Chen; Tzu-min Yeh; Anthony J Lee; Giovanni Schifitto; Kunling Wu; Ronald J Bosch; Justin C McArthur; David M Simpson; David B Clifford Journal: AIDS Date: 2011-04-24 Impact factor: 4.177
Authors: Joel E Gallant; Schlomo Staszewski; Anton L Pozniak; Edwin DeJesus; Jamal M A H Suleiman; Michael D Miller; Dion F Coakley; Biao Lu; John J Toole; Andrew K Cheng Journal: JAMA Date: 2004-07-14 Impact factor: 56.272