Literature DB >> 24873489

Biologically driven synthesis of pyrazolo[3,4-d]pyrimidines as protein kinase inhibitors: an old scaffold as a new tool for medicinal chemistry and chemical biology studies.

Silvia Schenone1, Marco Radi, Francesca Musumeci, Chiara Brullo, Maurizio Botta.   

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Year:  2014        PMID： 24873489     DOI： 10.1021/cr400270z

Source DB:  PubMed          Journal:  Chem Rev        ISSN： 0009-2665            Impact factor:   60.622


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  19 in total

1.  Predictive Gene Signature for Pyrazolopyrimidine Derivative c-Src Inhibitor 10a Sensitivity in Melanoma Cells.

Authors:  Baris Kucukkaraduman; Can Turk; Anna L Fallacara; Murat Isbilen; Kerem M Senses; Zeynep O Ayyildiz; Muhammad W Akbar; Michal Lotem; Maurizio Botta; Ali O Gure
Journal:  ACS Med Chem Lett       Date:  2020-02-18       Impact factor: 4.345

2.  Inhibition of Calcium Dependent Protein Kinase 1 (CDPK1) by Pyrazolopyrimidine Analogs Decreases Establishment and Reoccurrence of Central Nervous System Disease by Toxoplasma gondii.

Authors:  Florentine U Rutaganira; Jennifer Barks; Mary Savari Dhason; Qiuling Wang; Michael S Lopez; Shaojun Long; Joshua B Radke; Nathaniel G Jones; Amarendar R Maddirala; James W Janetka; Majida El Bakkouri; Raymond Hui; Kevan M Shokat; L David Sibley
Journal:  J Med Chem       Date:  2017-10-09       Impact factor: 7.446

3.  Water Solubility Enhancement of Pyrazolo[3,4-d]pyrimidine Derivatives via Miniaturized Polymer-Drug Microarrays.

Authors:  Monica Sanna; Giovanna Sicilia; Ali Alazzo; Nishant Singh; Francesca Musumeci; Silvia Schenone; Keith A Spriggs; Jonathan C Burley; Martin C Garnett; Vincenzo Taresco; Cameron Alexander
Journal:  ACS Med Chem Lett       Date:  2018-01-29       Impact factor: 4.345

4.  Design, Synthesis, and Biological Evaluation of Proteolysis Targeting Chimeras (PROTACs) for the Dual Degradation of IGF-1R and Src.

Authors:  Sudhakar Manda; Na Keum Lee; Dong-Chan Oh; Jeeyeon Lee
Journal:  Molecules       Date:  2020-04-23       Impact factor: 4.411

5.  Bisarylureas Based on 1H-Pyrazolo[3,4-d]pyrimidine Scaffold as Novel Pan-RAF Inhibitors with Potent Anti-Proliferative Activities: Structure-Based Design, Synthesis, Biological Evaluation and Molecular Modelling Studies.

Authors:  Yu Fu; Yuanyuan Wang; Shanhe Wan; Zhonghuang Li; Guangfa Wang; Jiajie Zhang; Xiaoyun Wu
Journal:  Molecules       Date:  2017-03-29       Impact factor: 4.411

6.  Rapid Discovery and Structure-Activity Relationships of Pyrazolopyrimidines That Potently Suppress Breast Cancer Cell Growth via SRC Kinase Inhibition with Exceptional Selectivity over ABL Kinase.

Authors:  Craig Fraser; John C Dawson; Reece Dowling; Douglas R Houston; Jason T Weiss; Alison F Munro; Morwenna Muir; Lea Harrington; Scott P Webster; Margaret C Frame; Valerie G Brunton; E Elizabeth Patton; Neil O Carragher; Asier Unciti-Broceta
Journal:  J Med Chem       Date:  2016-05-04       Impact factor: 7.446

7.  A convenient four-component one-pot strategy toward the synthesis of pyrazolo[3,4-d]pyrimidines.

Authors:  Mingxing Liu; Jiarong Li; Hongxin Chai; Kai Zhang; Deli Yang; Qi Zhang; Daxin Shi
Journal:  Beilstein J Org Chem       Date:  2015-11-06       Impact factor: 2.883

8.  Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity.

Authors:  Ho Jin Lee; Phuong Chi Pham; Seung Yeob Hyun; Byungyeob Baek; Byungjin Kim; Yunha Kim; Hye-Young Min; Jeeyeon Lee; Ho-Young Lee
Journal:  Mol Cancer       Date:  2018-02-19       Impact factor: 27.401

9.  Src Inhibitors Pyrazolo[3,4-d]pyrimidines, Si306 and Pro-Si306, Inhibit Focal Adhesion Kinase and Suppress Human Glioblastoma Invasion In Vitro and In Vivo.

Authors:  Marija Nešović; Aleksandra Divac Rankov; Ana Podolski-Renić; Igor Nikolić; Goran Tasić; Arianna Mancini; Silvia Schenone; Milica Pešić; Jelena Dinić
Journal:  Cancers (Basel)       Date:  2020-06-14       Impact factor: 6.639

10.  Phenylpyrazalopyrimidines as Tyrosine Kinase Inhibitors: Synthesis, Antiproliferative Activity, and Molecular Simulations.

Authors:  Bhupender S Chhikara; Sajda Ashraf; Saghar Mozaffari; Nicole St Jeans; Dindyal Mandal; Rakesh Kumar Tiwari; Zaheer Ul-Haq; Keykavous Parang
Journal:  Molecules       Date:  2020-05-02       Impact factor: 4.411
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