Literature DB >> 2487253

Immunomagnetic T-lymphocyte depletion (ITLD) of rat bone marrow using OX-19 monoclonal antibody.

A L Hoffman1, L Makowka, D V Cramer, X Cai, A Pascualone, B F Banner, D G Sheahan, P Rettinger, T E Starzl.   

Abstract

Graft versus host disease (GVHD) may be abrogated and host survival prolonged by in vitro depletion of T lymphocytes from bone marrow (BM) prior to allotransplantation. Using a mouse anti-rat pan T-lymphocyte monoclonal antibody (OX19) bound to monosized, magnetic, polymer beads, T lymphocytes were removed in vitro from normal bone marrow. The removal of the T lymphocytes was confirmed by flow cytometry. Injection of the T-lymphocyte-depleted bone marrow into fully allogeneic rats prevents the induction of GVHD and prolongs host survival.

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Year:  1989        PMID： 2487253      PMCID： PMC2975399          DOI： 10.3109/08941938909057430

Source DB:  PubMed          Journal:  J Invest Surg        ISSN： 0894-1939            Impact factor:   2.533


  21 in total

Review 1.  Graft-vs.-host reactions: mechanisms and contemporary theories.

Authors:  H Bril; R Benner
Journal:  Crit Rev Clin Lab Sci       Date:  1985       Impact factor: 6.250

2.  Depletion of T lymphocytes from human bone marrow. Use of magnetic monosized polymer microspheres coated with T-lymphocyte-specific monoclonal antibodies.

Authors:  F Vartdal; G Kvalheim; T E Lea; V Bosnes; G Gaudernack; J Ugelstad; D Albrechtsen
Journal:  Transplantation       Date:  1987-03       Impact factor: 4.939

3.  Effects of in vitro depletion of T cells in HLA-identical allogeneic marrow grafts.

Authors:  P J Martin; J A Hansen; C D Buckner; J E Sanders; H J Deeg; P Stewart; F R Appelbaum; R Clift; A Fefer; R P Witherspoon
Journal:  Blood       Date:  1985-09       Impact factor: 22.113

4.  Cellular immunoabsorption using monoclonal antibodies. Selective removal of T cells from peripheral blood and bone marrow.

Authors:  R J Berenson; L J Levitt; R Levy; R A Miller
Journal:  Transplantation       Date:  1984-08       Impact factor: 4.939

5.  Elimination of graft-versus-host disease by in-vitro depletion of alloreactive lymphocytes with a monoclonal rat anti-human lymphocyte antibody (CAMPATH-1).

Authors:  H Waldmann; A Polliak; G Hale; R Or; G Cividalli; L Weiss; Z Weshler; S Samuel; D Manor; C Brautbar
Journal:  Lancet       Date:  1984-09-01       Impact factor: 79.321

6.  Ex-vivo treatment of donor bone marrow with anti-T-cell immunotoxins for prevention of graft-versus-host disease.

Authors:  A H Filipovich; D A Vallera; R J Youle; R R Quinones; D M Neville; J H Kersey
Journal:  Lancet       Date:  1984-03-03       Impact factor: 79.321

7.  Elimination of B-lymphoma cells from human bone marrow: model experiments using monodisperse magnetic particles coated with primary monoclonal antibodies.

Authors:  G Kvalheim; O Fodstad; A Pihl; K Nustad; A Pharo; J Ugelstad; S Funderud
Journal:  Cancer Res       Date:  1987-02-01       Impact factor: 12.701

8.  Postirradiation recovery of lymphoid cells in the rat.

Authors:  A Farnsworth; J S Wotherspoon; S E Dorsch
Journal:  Transplantation       Date:  1988-09       Impact factor: 4.939

9.  The genetics of bone marrow transplantation in the rat.

Authors:  M K Oaks; D V Cramer
Journal:  Transplantation       Date:  1985-01       Impact factor: 4.939

10.  Induction of Ia antigen in rat epidermal cells and gut epithelium by immunological stimuli.

Authors:  A N Barclay; D W Mason
Journal:  J Exp Med       Date:  1982-12-01       Impact factor: 14.307
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  1 in total

1.  Induction of stable chimerism and elimination of graft-versus-host disease by depletion of T lymphocytes from bone marrow using immunomagnetic beads.

Authors:  A L Hoffman; L Makowka; D V Cramer; X Cai; B Banner; A Pascualone; S Hoffmann; T E Starzl
Journal:  Surgery       Date:  1989-08       Impact factor: 3.982
  1 in total

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