Literature DB >> 24872515

Macrophage depletion prior to Neospora caninum infection results in severe neosporosis in mice.

Chisa Abe1, Sachi Tanaka2, Fumiaki Ihara1, Yoshifumi Nishikawa3.   

Abstract

We observed that murine macrophages showed greater activation and increased interleukin 6 (IL-6), IL-12p40, and interferon gamma (IFN-γ) production during Neospora caninum infection. Many macrophages migrated to the site of infection. Furthermore, macrophage-depleted mice exhibited increased sensitivity to N. caninum infection. This study indicates that macrophages are required for achieving protective immunity against N. caninum.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24872515      PMCID： PMC4135910          DOI： 10.1128/CVI.00082-14

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  16 in total

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6.  In the absence of endogenous gamma interferon, mice acutely infected with Neospora caninum succumb to a lethal immune response characterized by inactivation of peritoneal macrophages.

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  13 in total

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Authors:  Yoshifumi Nishikawa; Naomi Shimoda; Ragab M Fereig; Tomoya Moritaka; Kousuke Umeda; Maki Nishimura; Fumiaki Ihara; Kaoru Kobayashi; Yuu Himori; Yutaka Suzuki; Hidefumi Furuoka
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4.  Role of the chemokine receptor CCR5-dependent host defense system in Neospora caninum infections.

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6.  Bovine Polymorphonuclear Neutrophils Cast Neutrophil Extracellular Traps against the Abortive Parasite Neospora caninum.

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9.  Changes in neurotransmitter levels and expression of immediate early genes in brain of mice infected with Neospora caninum.

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10.  NLRP3 Inflammasome Participates in Host Response to Neospora caninum Infection.

Authors:  Xiaocen Wang; Pengtao Gong; Xu Zhang; Shan Li; Xiangyun Lu; Chunyan Zhao; Qile Yu; Zhengkai Wei; Yongjun Yang; Qun Liu; Zhengtao Yang; Jianhua Li; Xichen Zhang
Journal:  Front Immunol       Date:  2018-07-30       Impact factor: 7.561
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