Azar Kariminia1, Nicolas Durier, Gonzague Jourdain, Suneeta Saghayam, Chau V Do, Lam Van Nguyen, Rawiwan Hansudewechakul, Pagakrong Lumbiganon, Kulkanya Chokephaibulkit, Khanh Huu Truong, Virat Sirisanthana, Vibol Ung, Saphonn Vonthanak, Jintanat Ananworanich, Nik Khairulddin Nik Yusoff, Nia Kurniati, Kamarul Azahar Razali, Moy Siew Fong, Revathy Nallusamy, Dewi Kumara Wati. 1. *The Kirby Institute, Faculty of Medicine, University of New South Wales, Sydney, Australia; †TREAT Asia/amfAR-The Foundation for AIDS Research, Bangkok, Thailand; ‡Programs for HIV Prevention and Treatment, Institut de Recherche pour le Développement, France, and Chiang Mai University, Chiang Mai, Thailand; §YR Gaitonde Centre for AIDS Research and Education, Chennai, India; ‖Infectious Disease Department, Children's Hospital 2, Ho Chi Minh City, Vietnam; ¶Infectious Disease Department, National Hospital of Pediatrics, Hanoi, Vietnam; #Pediatric Department, Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand; **Pediatric Department , Khon Kaen University, Khon Kaen, Thailand; ††Pediatric Department , Siriraj Hospital, Mahidol University, Bangkok, Thailand; ‡‡Infectious Disease Department, Children's Hospital 1, Ho Chi Minh City, Vietnam; §§Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; ‖‖TB/HIV Department, National Pediatric Hospital, Phnom Penh, Cambodia; ¶¶Research Unit, National Centre for HIV/AIDS, Dermatology and STDs, Phnom Penh, Cambodia; ##HIV-NAT/Thai Red Cross AIDS Research Centre, Bangkok, Thailand; ***Department of Pediatrics, Hospital Raja Perempuan Zainab II, Kelantan, Malaysia; †††Pediatric Allergy-Immunology Division, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; ‡‡‡Pediatric Institute, Hospital Kuala Lumpur, Kuala Lumpur, Malaysia; §§§Department of Pediatrics, Hospital Likas, Kota Kinabalu, Malaysia; ‖‖‖Department of Pediatrics, Penang Hospital, Penang, Malaysia; and ¶¶¶Allergy-Immunology Division, Sanglah Hospital, Udayana University, Bali, Indonesia.
Abstract
OBJECTIVE: To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART). METHODS: We used Cox regression to analyze data of a cohort of Asian children. RESULTS: A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score < -3 was associated with mortality (P < 0.001) independent of CD4% and < -2 was associated with immunological failure (P ≤ 0.03) independent of age at cART. CONCLUSIONS: Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.
OBJECTIVE: To evaluate the value of time-updated weight and height in predicting clinical progression, and immunological and virological failure in children receiving combination antiretroviral therapy (cART). METHODS: We used Cox regression to analyze data of a cohort of Asian children. RESULTS: A total of 2608 children were included; median age at cART was 5.7 years. Time-updated weight for age z score < -3 was associated with mortality (P < 0.001) independent of CD4% and < -2 was associated with immunological failure (P ≤ 0.03) independent of age at cART. CONCLUSIONS: Weight monitoring provides useful data to inform clinical management of children on cART in resource-limited settings.
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