Literature DB >> 24871906

Palladium catalyzed, heteroatom-guided C-H functionalization in the synthesis of substituted isoquinolines and dihydroisoquinolines.

Virendra Kumar Tiwari1, Govind Goroba Pawar, Himanshu Sekhar Jena, Manmohan Kapur.   

Abstract

A new approach for the functionalization of C-4 of isoquinolines is reported. The method utilizes palladium catalyzed, hetero-atom guided (or electrophilic metalation) direct arylation via regioselective C-H functionalization of dihydroisoquinolines.

Entities:  

Year:  2014        PMID： 24871906     DOI： 10.1039/c4cc03165b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  2 in total

1.  Aminomethylation/hydrogenolysis as an alternative to direct methylation of metalated isoquinolines - a novel total synthesis of the alkaloid 7-hydroxy-6-methoxy-1-methylisoquinoline.

Authors:  Benedikt C Melzer; Jan G Felber; Franz Bracher
Journal:  Beilstein J Org Chem       Date:  2018-01-11       Impact factor: 2.883

2.  Visible Light-Enabled sp3 -C-H Functionalization with Chloro- and Bromoalkynes: Chemoselective Route to Vinylchlorides or Alkynes.

Authors:  Tapas Adak; Marvin Hoffmann; Sina Witzel; Matthias Rudolph; Andreas Dreuw; A Stephen K Hashmi
Journal:  Chemistry       Date:  2020-10-15       Impact factor: 5.236
  2 in total

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