Literature DB >> 24871610

The role of epigenetics in colorectal cancer.

Fabio Coppedè1.   

Abstract

Colorectal cancer (CRC) results from a stepwise accumulation of genetic and epigenetic alterations that transform the normal colonic epithelium into cancer. DNA methylation represents one of the most studied epigenetic marks in CRC, and three common epigenotypes have been identified characterized by high, intermediate and low methylation profiles, respectively. Combining DNA methylation data with gene mutations and cytogenetic alterations occurring in CRC is nowadays allowing the characterization of different CRC subtypes, but the crosstalk between DNA methylation and other epigenetic mechanisms, such as histone tail modifications and the deregulated expression of non-coding RNAs is not yet clearly defined. Epigenetic biomarkers are increasingly recognized as promising diagnostic and prognostic tools in CRC, and the potential of therapeutic applications aimed at targeting the epigenome is under investigation.

Entities:  

Keywords:  DNA methylation; colorectal cancer; epigenetics; epigenotype; histone acetylation; histone methylation; histone tail modification; miRNA; non-coding RNA

Mesh：

Substances：

Year:  2014        PMID： 24871610     DOI： 10.1586/17474124.2014.924397

Source DB:  PubMed          Journal:  Expert Rev Gastroenterol Hepatol        ISSN： 1747-4124            Impact factor:   3.869


  17 in total

1.  The anti-tumor effects of Mfn2 in breast cancer are dependent on promoter DNA methylation, the P21Ras motif and PKA phosphorylation site.

Authors:  Yufeng Li; Wenyue Dong; Xijin Shan; Hui Hong; Yan Liu; Yankun Liu; Xiaohui Liu; Xiaojun Zhang; Jinghua Zhang
Journal:  Oncol Lett       Date:  2018-03-21       Impact factor: 2.967

2.  Review Article: The Role of Molecular Pathological Epidemiology in the Study of Neoplastic and Non-neoplastic Diseases in the Era of Precision Medicine.

Authors:  Shuji Ogino; Reiko Nishihara; Tyler J VanderWeele; Molin Wang; Akihiro Nishi; Paul Lochhead; Zhi Rong Qian; Xuehong Zhang; Kana Wu; Hongmei Nan; Kazuki Yoshida; Danny A Milner; Andrew T Chan; Alison E Field; Carlos A Camargo; Michelle A Williams; Edward L Giovannucci
Journal:  Epidemiology       Date:  2016-07       Impact factor: 4.822

Review 3.  Colorectal cancer: epigenetic alterations and their clinical implications.

Authors:  Alberto Puccini; Martin D Berger; Madiha Naseem; Ryuma Tokunaga; Francesca Battaglin; Shu Cao; Diana L Hanna; Michelle McSkane; Shivani Soni; Wu Zhang; Heinz-Josef Lenz
Journal:  Biochim Biophys Acta Rev Cancer       Date:  2017-09-20       Impact factor: 10.680

4.  Proceedings of the second international molecular pathological epidemiology (MPE) meeting.

Authors:  Shuji Ogino; Peter T Campbell; Reiko Nishihara; Amanda I Phipps; Andrew H Beck; Mark E Sherman; Andrew T Chan; Melissa A Troester; Adam J Bass; Kathryn C Fitzgerald; Rafael A Irizarry; Karl T Kelsey; Hongmei Nan; Ulrike Peters; Elizabeth M Poole; Zhi Rong Qian; Rulla M Tamimi; Eric J Tchetgen Tchetgen; Shelley S Tworoger; Xuehong Zhang; Edward L Giovannucci; Piet A van den Brandt; Bernard A Rosner; Molin Wang; Nilanjan Chatterjee; Colin B Begg
Journal:  Cancer Causes Control       Date:  2015-05-09       Impact factor: 2.506

Review 5.  Integration of molecular pathology, epidemiology and social science for global precision medicine.

Authors:  Akihiro Nishi; Danny A Milner; Edward L Giovannucci; Reiko Nishihara; Andy S Tan; Ichiro Kawachi; Shuji Ogino
Journal:  Expert Rev Mol Diagn       Date:  2015-12-04       Impact factor: 5.225

6.  Epigenetics and Colorectal Neoplasia: the Evidence for Physical Activity and Sedentary Behavior.

Authors:  Elizabeth Hibler
Journal:  Curr Colorectal Cancer Rep       Date:  2015-09-19

7.  Epigenetics override pro-inflammatory PTGS transcriptomic signature towards selective hyperactivation of PGE2 in colorectal cancer.

Authors:  Inês Cebola; Joaquin Custodio; Mar Muñoz; Anna Díez-Villanueva; Laia Paré; Patricia Prieto; Susanna Aussó; Llorenç Coll-Mulet; Lisardo Boscá; Victor Moreno; Miguel A Peinado
Journal:  Clin Epigenetics       Date:  2015-07-24       Impact factor: 6.551

Review 8.  The role of dietary histone deacetylases (HDACs) inhibitors in health and disease.

Authors:  Shalome A Bassett; Matthew P G Barnett
Journal:  Nutrients       Date:  2014-10-15       Impact factor: 5.717

9.  Histone Methylation Marks on Circulating Nucleosomes as Novel Blood-Based Biomarker in Colorectal Cancer.

Authors:  Ugur Gezer; Ebru E Yörüker; Metin Keskin; Cemil Burak Kulle; Yoganiranjana Dharuman; Stefan Holdenrieder
Journal:  Int J Mol Sci       Date:  2015-12-11       Impact factor: 5.923

10.  IFN-α potentiates the direct and immune-mediated antitumor effects of epigenetic drugs on both metastatic and stem cells of colorectal cancer.

Authors:  Maria Buoncervello; Giulia Romagnoli; Mariachiara Buccarelli; Alessandra Fragale; Elena Toschi; Stefania Parlato; Donatella Lucchetti; Daniele Macchia; Massimo Spada; Irene Canini; Massimo Sanchez; Mario Falchi; Martina Musella; Mauro Biffoni; Filippo Belardelli; Imerio Capone; Alessandro Sgambato; Lucia Ricci Vitiani; Lucia Gabriele
Journal:  Oncotarget       Date:  2016-05-03
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