Literature DB >> 24870379

Designed cell penetrating peptide dendrimers efficiently internalize cargo into cells.

Gabriela A Eggimann1, Emilyne Blattes, Stefanie Buschor, Rasomoy Biswas, Stephan M Kammer, Tamis Darbre, Jean-Louis Reymond.   

Abstract

Redesigning linear cell penetrating peptides (CPPs) into a multi-branched topology with short dipeptide branches gave cell penetrating peptide dendrimers (CPPDs) with higher cell penetration, lower toxicity and hemolysis and higher serum stability than linear CPPs. Their use is demonstrated by delivering a cytotoxic peptide and paclitaxel into cells.

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Year:  2014        PMID： 24870379     DOI： 10.1039/c4cc02780a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  8 in total

Review 1.  Redesigning of Cell-Penetrating Peptides to Improve Their Efficacy as a Drug Delivery System.

Authors:  Ildikó Szabó; Mo'ath Yousef; Dóra Soltész; Csaba Bató; Gábor Mező; Zoltán Bánóczi
Journal:  Pharmaceutics       Date:  2022-04-21       Impact factor: 6.525

2.  Silencing of SARS-CoV-2 with modified siRNA-peptide dendrimer formulation.

Authors:  Musa Khaitov; Alexandra Nikonova; Igor Shilovskiy; Ksenia Kozhikhova; Ilya Kofiadi; Lyudmila Vishnyakova; Alexander Nikolskii; Pia Gattinger; Valeria Kovchina; Ekaterina Barvinskaia; Kirill Yumashev; Valeriy Smirnov; Artem Maerle; Ivan Kozlov; Artem Shatilov; Anastasiia Timofeeva; Sergey Andreev; Olesya Koloskova; Nadezhda Kuznetsova; Daria Vasina; Maria Nikiforova; Sergei Rybalkin; Ilya Sergeev; Dmitriy Trofimov; Alexander Martynov; Igor Berzin; Vladimir Gushchin; Aleksey Kovalchuk; Sergei Borisevich; Rudolf Valenta; Rakhim Khaitov; Veronica Skvortsova
Journal:  Allergy       Date:  2021-05-10       Impact factor: 14.710

3.  Synthesis of novel peptide dendrimers PDL-GB2 and PDL-G2.

Authors:  Lin Yunzhu; Weng Lingling; Qi Qingrong
Journal:  ScientificWorldJournal       Date:  2015-03-22

4.  Design, crystal structure and atomic force microscopy study of thioether ligated d,l-cyclic antimicrobial peptides against multidrug resistant Pseudomonas aeruginosa.

Authors:  Runze He; Ivan Di Bonaventura; Ricardo Visini; Bee-Ha Gan; Yongchun Fu; Daniel Probst; Alexandre Lüscher; Thilo Köhler; Christian van Delden; Achim Stocker; Wenjing Hong; Tamis Darbre; Jean-Louis Reymond
Journal:  Chem Sci       Date:  2017-09-04       Impact factor: 9.825

5.  Branched BBB-shuttle peptides: chemoselective modification of proteins to enhance blood-brain barrier transport.

Authors:  Cristina Díaz-Perlas; Benjamí Oller-Salvia; Macarena Sánchez-Navarro; Meritxell Teixidó; Ernest Giralt
Journal:  Chem Sci       Date:  2018-09-18       Impact factor: 9.825

6.  Comparison of bulk and microfluidics methods for the formulation of poly-lactic-co-glycolic acid (PLGA) nanoparticles modified with cell-penetrating peptides of different architectures.

Authors:  Sarah Streck; Henriette Neumann; Hanne Mørck Nielsen; Thomas Rades; Arlene McDowell
Journal:  Int J Pharm X       Date:  2019-08-13

7.  Lipophilic Peptide Dendrimers for Delivery of Splice-Switching Oligonucleotides.

Authors:  Haneen Daralnakhla; Osama Saher; Susanna Zamolo; Safa Bazaz; Jeremy P Bost; Marc Heitz; Karin E Lundin; Samir El Andaloussi; Tamis Darbre; Jean-Louis Reymond; Rula Zain; C I Edvard Smith
Journal:  Pharmaceutics       Date:  2021-01-18       Impact factor: 6.321

Review 8.  The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions.

Authors:  Bee Ha Gan; Josephine Gaynord; Sam M Rowe; Tomas Deingruber; David R Spring
Journal:  Chem Soc Rev       Date:  2021-07-05       Impact factor: 54.564
  8 in total

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