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Literature DB >> 24869958

Advances in mesenchymal stem cell-based strategies for cartilage repair and regeneration.

Wei Seong Toh¹, Casper Bindzus Foldager, Ming Pei, James Hoi Po Hui.

Abstract

Significant research efforts have been undertaken in the last decade in the development of stem cell-based therapies for cartilage repair. Among the various stem cell sources, mesenchymal stem cells (MSCs) demonstrate great promise and clinical efficacy in cartilage regeneration. With a deeper understanding of stem cell biology, new therapeutics and new bioengineering approaches have emerged and showed potential for further developments. Of note, there has been a paradigm shift in applying MSCs for tissue regeneration from the use of stem cells for transplantation to the use of stem cell-derived matrix and secretome components as therapeutic tools and agents for cartilage regeneration. In this review, we will discuss the emerging role of MSCs in cartilage regeneration and the most recent advances in development of stem cell-based therapeutics for cartilage regeneration.

Entities: Disease

Mesh：

Year: 2014 PMID： 24869958 DOI： 10.1007/s12015-014-9526-z

Source DB: PubMed Journal: Stem Cell Rev Rep ISSN： 2629-3277 Impact factor: 5.739

117 in total

1. Optimization of an in vitro three-dimensional microenvironment to reprogram synovium-derived stem cells for cartilage tissue engineering.

Authors: Jingting Li; Ming Pei
Journal: Tissue Eng Part A Date: 2010-12-18 Impact factor: 3.845

Review 2. Potential of human embryonic stem cells in cartilage tissue engineering and regenerative medicine.

Authors: Wei Seong Toh; Eng Hin Lee; Tong Cao
Journal: Stem Cell Rev Rep Date: 2011-09 Impact factor: 5.739

3. Trophic effects of mesenchymal stem cells increase chondrocyte proliferation and matrix formation.

Authors: Ling Wu; Jeroen C H Leijten; Nicole Georgi; Janine N Post; Clemens A van Blitterswijk; Marcel Karperien
Journal: Tissue Eng Part A Date: 2011-02-28 Impact factor: 3.845

Review 4. Antiangiogenic and anticancer molecules in cartilage.

Authors: Debabrata Patra; Linda J Sandell
Journal: Expert Rev Mol Med Date: 2012-01-19 Impact factor: 5.600

5. Human fibroblast matrices bio-assembled under macromolecular crowding support stable propagation of human embryonic stem cells.

Authors: Yanxian Peng; Michael Thomas Bocker; Jennifer Holm; Wei Seong Toh; Christopher Stephen Hughes; Fahad Kidwai; Gilles Andre Lajoie; Tong Cao; Frank Lyko; Michael Raghunath
Journal: J Tissue Eng Regen Med Date: 2012-07-03 Impact factor: 3.963

6. Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2.

Authors: Cristina Manferdini; Marie Maumus; Elena Gabusi; Anna Piacentini; Giuseppe Filardo; Julie-Anne Peyrafitte; Christian Jorgensen; Philippe Bourin; Sandrine Fleury-Cappellesso; Andrea Facchini; Danièle Noël; Gina Lisignoli
Journal: Arthritis Rheum Date: 2013-05

Review 7. Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors.

Authors: Stephane Boeuf; Wiltrud Richter
Journal: Stem Cell Res Ther Date: 2010-10-13 Impact factor: 6.832

Review 8. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine.

Authors: G T-J Huang; S Gronthos; S Shi
Journal: J Dent Res Date: 2009-09 Impact factor: 6.116

Review 9. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects.

Authors: E B Hunziker
Journal: Osteoarthritis Cartilage Date: 2002-06 Impact factor: 6.576

10. Delivery of basic fibroblast growth factors from heparinized decellularized adipose tissue stimulates potent de novo adipogenesis.

Authors: Qiqi Lu; Mingming Li; Yu Zou; Tong Cao
Journal: J Control Release Date: 2013-11-15 Impact factor: 9.776

44 in total

Advances in mesenchymal stem cell-based strategies for cartilage repair and regeneration.

1. Optimization of an in vitro three-dimensional microenvironment to reprogram synovium-derived stem cells for cartilage tissue engineering.

Review 2. Potential of human embryonic stem cells in cartilage tissue engineering and regenerative medicine.

3. Trophic effects of mesenchymal stem cells increase chondrocyte proliferation and matrix formation.

Review 4. Antiangiogenic and anticancer molecules in cartilage.

5. Human fibroblast matrices bio-assembled under macromolecular crowding support stable propagation of human embryonic stem cells.

6. Adipose-derived mesenchymal stem cells exert antiinflammatory effects on chondrocytes and synoviocytes from osteoarthritis patients through prostaglandin E2.

Review 7. Chondrogenesis of mesenchymal stem cells: role of tissue source and inducing factors.

Review 8. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine.

Review 9. Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects.

10. Delivery of basic fibroblast growth factors from heparinized decellularized adipose tissue stimulates potent de novo adipogenesis.

Review 1. The role of laminins in cartilaginous tissues: from development to regeneration.

Review 2. Environmental preconditioning rejuvenates adult stem cells' proliferation and chondrogenic potential.

3. Current concepts in the articular cartilage repair and regeneration.

Review 4. Tissue Engineering for the Temporomandibular Joint.

Review 5. Stem Cells for Temporomandibular Joint Repair and Regeneration.

Review 6. Mesenchymal stem cell related therapies for cartilage lesions and osteoarthritis.

7. A Road Map to Commercialization of Cartilage Therapy in the United States of America.

Review 8. Mesenchymal Stem Cell-Derived Extracellular Vesicles: The Novel Therapeutic Option for Regenerative Dentistry.

9. Combined Bone Marrow Aspirate and Platelet-Rich Plasma for Cartilage Repair: Two-Year Clinical Results.

10. Collagen Type II enhances chondrogenic differentiation in agarose-based modular microtissues.