Literature DB >> 24868444

The biomolecular era for thoracic surgeons: the example of the ESTS Biology Club.

Isabelle Opitz1, Thomas A D'Amico1, Gaetano Rocco1.   

Abstract

Understanding basic mechanisms of lung disease may help to move forward the management of our patients. Molecular biology has affected our diagnostic and therapeutic pathways in the direction of personalized medicine not only for thoracic malignancies. Accordingly, thoracic surgeons are becoming increasingly aware that specific knowledge of genetic and epigenetic alterations may influence their clinical behavior-from the ward to the operating room (OR). In this continuously evolving scenario, surgical societies have perceived the increasing relevance of biomolecular medicine in the practice of modern thoracic surgery. More recently, in the spirit of mutual collaboration between sister societies, the European Society of Thoracic Surgeons (ESTS) has adopted the concept of the American Association for Thoracic Surgery (AATS) incorporating one session dedicated to the Biology Club within the Annual Meeting Program. The aim of the ESTS Biology Club is to outline and sponsor the new profile of the surgeon scientist during the only world meeting exclusively focused on general thoracic surgery. The following article will summarize the significance of this and give an update on molecular biology tools for thoracic malignancies.

Entities:  

Keywords:  Molecular biology; mesothelioma; non-small cell lung cancer (NSCLC); the European Society of Thoracic Surgeons (ESTS); thoracic surgery

Year:  2014        PMID: 24868444      PMCID: PMC4032959          DOI: 10.3978/j.issn.2072-1439.2014.05.01

Source DB:  PubMed          Journal:  J Thorac Dis        ISSN: 2072-1439            Impact factor:   2.895


  49 in total

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Journal:  Lung Cancer       Date:  2014-03-02       Impact factor: 5.705

2.  The surgeon's role in molecular biology.

Authors:  Gaetano Rocco
Journal:  J Thorac Cardiovasc Surg       Date:  2012-06-26       Impact factor: 5.209

3.  The nuclear deubiquitinase BAP1 is commonly inactivated by somatic mutations and 3p21.1 losses in malignant pleural mesothelioma.

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Journal:  Nat Genet       Date:  2011-06-05       Impact factor: 38.330

4.  Merlin/NF2 suppresses tumorigenesis by inhibiting the E3 ubiquitin ligase CRL4(DCAF1) in the nucleus.

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Journal:  Cell       Date:  2010-02-19       Impact factor: 41.582

Review 5.  Recent advances in non-small cell lung cancer biology and clinical management.

Authors:  Pierre Saintigny; Jan A Burger
Journal:  Discov Med       Date:  2012-04       Impact factor: 2.970

Review 6.  MicroRNA in lung cancer.

Authors:  P-Y Lin; S-L Yu; P-C Yang
Journal:  Br J Cancer       Date:  2010-09-21       Impact factor: 7.640

7.  Codeletion of p15 and p16 in primary malignant mesothelioma.

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Journal:  Oncogene       Date:  1995-08-03       Impact factor: 9.867

8.  Germline BAP1 mutations predispose to malignant mesothelioma.

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Journal:  Nat Genet       Date:  2011-08-28       Impact factor: 38.330

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Journal:  Br J Cancer       Date:  1997       Impact factor: 7.640

10.  Allelic imbalance in 1p, 7q, 9p, 11p, 12q and 16q regions in non-small cell lung carcinoma and its clinical association: a pilot study.

Authors:  Karolina H Czarnecka; Monika Migdalska-Sęk; Adam Antczak; Dorota Pastuszak-Lewandoska; Jacek Kordiak; Ewa Nawrot; Daria Domańska; Dorota Kaleta; Paweł Górski; Ewa Barbara Brzeziańska
Journal:  Mol Biol Rep       Date:  2013-10-04       Impact factor: 2.316

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  1 in total

Review 1.  Translational research in thoracic surgery-the National Taiwan University Hospital experience.

Authors:  Mong-Wei Lin; Pei-Wen Yang; Jang-Ming Lee
Journal:  J Thorac Dis       Date:  2016-08       Impact factor: 2.895

  1 in total

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