Literature DB >> 2486822

The active site of cytochrome P-450 nifedipine oxidase: a model-building study.

G G Ferenczy1, G M Morris.   

Abstract

A model of the active site of cytochrome P-450 nifedipine oxidase is built on the basis of sequence homology with cytochrome P-450CAM. Substrates are docked into the binding pocket, and molecular mechanical energy minimization is performed to analyze the forces between the substrates and the enzyme.

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Year:  1989        PMID： 2486822     DOI： 10.1016/0263-7855(89)80004-9

Source DB:  PubMed          Journal:  J Mol Graph        ISSN： 0263-7855


  3 in total

1.  The sequence homologies of cytochromes P-450 and active-site geometries.

Authors:  D F Lewis; H Moereels
Journal:  J Comput Aided Mol Des       Date:  1992-06       Impact factor: 3.686

Review 2.  The gut as a barrier to drug absorption: combined role of cytochrome P450 3A and P-glycoprotein.

Authors:  Y Zhang; L Z Benet
Journal:  Clin Pharmacokinet       Date:  2001       Impact factor: 6.447

3.  A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building.

Authors:  L M Koymans; N P Vermeulen; A Baarslag; G M Donné-Op den Kelder
Journal:  J Comput Aided Mol Des       Date:  1993-06       Impact factor: 3.686
  3 in total

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