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Literature DB >> 24867973

SAMHD1 has differential impact on the efficacies of HIV nucleoside reverse transcriptase inhibitors.

Andrew D Huber¹, Eleftherios Michailidis², Megan L Schultz³, Yee T Ong², Nicolin Bloch³, Maritza N Puray-Chavez², Maxwell D Leslie², Juan Ji², Anthony D Lucas², Karen A Kirby², Nathaniel R Landau³, Stefan G Sarafianos⁴.

Abstract

Sterile alpha motif- and histidine/aspartic acid domain-containing protein 1 (SAMHD1) limits HIV-1 replication by hydrolyzing deoxynucleoside triphosphates (dNTPs) necessary for reverse transcription. Nucleoside reverse transcriptase inhibitors (NRTIs) are components of anti-HIV therapies. We report here that SAMHD1 cleaves NRTI triphosphates (TPs) at significantly lower rates than dNTPs and that SAMHD1 depletion from monocytic cells affects the susceptibility of HIV-1 infections to NRTIs in complex ways that depend not only on the relative changes in dNTP and NRTI-TP concentrations but also on the NRTI activation pathways.

Entities: Chemical Disease Gene Species

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Year: 2014 PMID： 24867973 PMCID： PMC4136039 DOI： 10.1128/AAC.02745-14

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

63 in total

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3. Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society-USA panel.

Authors: Scott M Hammer; Michael S Saag; Mauro Schechter; Julio S G Montaner; Robert T Schooley; Donna M Jacobsen; Melanie A Thompson; Charles C J Carpenter; Margaret A Fischl; Brian G Gazzard; Jose M Gatell; Martin S Hirsch; David A Katzenstein; Douglas D Richman; Stefano Vella; Patrick G Yeni; Paul A Volberding
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Authors: Eleftherios Michailidis; Bruno Marchand; Eiichi N Kodama; Kamlendra Singh; Masao Matsuoka; Karen A Kirby; Emily M Ryan; Ali M Sawani; Eva Nagy; Noriyuki Ashida; Hiroaki Mitsuya; Michael A Parniak; Stefan G Sarafianos
Journal: J Biol Chem Date: 2009-12-18 Impact factor: 5.157

6. Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase.

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9. SIVSM/HIV-2 Vpx proteins promote retroviral escape from a proteasome-dependent restriction pathway present in human dendritic cells.

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10. Restriction of diverse retroviruses by SAMHD1.

Authors: Thomas Gramberg; Tanja Kahle; Nicolin Bloch; Sabine Wittmann; Erik Müllers; Waaqo Daddacha; Henning Hofmann; Baek Kim; Dirk Lindemann; Nathaniel R Landau
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Authors: Joseph A Hollenbaugh; Susan M Schader; Raymond F Schinazi; Baek Kim
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Authors: Kyle J Seamon; James T Stivers
Journal: J Biomol Screen Date: 2015-03-09

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4. Select host restriction factors are associated with HIV persistence during antiretroviral therapy.

Authors: Mohamed Abdel-Mohsen; Charlene Wang; Matthew C Strain; Steven M Lada; Xutao Deng; Leslie R Cockerham; Christopher D Pilcher; Frederick M Hecht; Teri Liegler; Douglas D Richman; Steven G Deeks; Satish K Pillai
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7. Increased SAMHD1 transcript expression correlates with interferon-related genes in HIV-1-infected patients.

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Journal: Med Microbiol Immunol Date: 2018-12-18 Impact factor: 4.148