Literature DB >> 24867972

Association between pncA gene mutations, pyrazinamidase activity, and pyrazinamide susceptibility testing in Mycobacterium tuberculosis.

Akio Aono1, Kinuyo Chikamatsu2, Hiroyuki Yamada2, Tomoko Kato3, Satoshi Mitarai3.   

Abstract

We determined MICs for, confirmed the presence of pncA mutations in, and performed pyrazinamidase testing on colonies (subclones) obtained from seven isolates that exhibited differential pyrazinamide (PZA) susceptibility. Six of the seven strains were found to exhibit characteristics resulting from the mixture of strains possessing different properties. In addition, our analysis revealed large pncA-spanning deletions (1,565 bp, 4,475 bp, and 6,258 bp) in three strains that showed high PZA resistance.
Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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Year:  2014        PMID： 24867972      PMCID： PMC4136016          DOI： 10.1128/AAC.02394-14

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  16 in total

1.  pncA mutations in pyrazinamide-resistant Mycobacterium tuberculosis isolates from northwestern Russia.

Authors:  H J Marttila; M Marjamäki; E Vyshnevskaya; B I Vyshnevskiy; T F Otten; A V Vasilyef; M K Viljanen
Journal:  Antimicrob Agents Chemother       Date:  1999-07       Impact factor: 5.191

2.  Activation of pyrazinamide and nicotinamide in acidic environments in vitro.

Authors:  W McDERMOTT; R TOMPSETT
Journal:  Am Rev Tuberc       Date:  1954-10

3.  Conditions that may affect the results of susceptibility testing of Mycobacterium tuberculosis to pyrazinamide.

Authors:  Ying Zhang; Sallie Permar; Zhonghe Sun
Journal:  J Med Microbiol       Date:  2002-01       Impact factor: 2.472

4.  Pyrazinamide sterilizing activity in vitro against semidormant Mycobacterium tuberculosis bacterial populations.

Authors:  L Heifets; P Lindholm-Levy
Journal:  Am Rev Respir Dis       Date:  1992-05

5.  Simple pyrazinamidase and urease tests for routine identification of mycobacteria.

Authors:  L G Wayne
Journal:  Am Rev Respir Dis       Date:  1974-01

6.  Mutations associated with pyrazinamide resistance in pncA of Mycobacterium tuberculosis complex organisms.

Authors:  S Sreevatsan; X Pan; Y Zhang; B N Kreiswirth; J M Musser
Journal:  Antimicrob Agents Chemother       Date:  1997-03       Impact factor: 5.191

7.  Mutations in pncA, a gene encoding pyrazinamidase/nicotinamidase, cause resistance to the antituberculous drug pyrazinamide in tubercle bacillus.

Authors:  A Scorpio; Y Zhang
Journal:  Nat Med       Date:  1996-06       Impact factor: 53.440

8.  Controlled clinical trial of 4 short-course regimens of chemotherapy (three 6-month and one 8-month) for pulmonary tuberculosis: final report. East and Central African/British Medical Research Council Fifth Collaborative Study.

Authors: 
Journal:  Tubercle       Date:  1986-03

9.  pncA gene expression and prediction factors on pyrazinamide resistance in Mycobacterium tuberculosis.

Authors:  Patricia Sheen; Katherine Lozano; Robert H Gilman; Hugo J Valencia; Sebastian Loli; Patricia Fuentes; Louis Grandjean; Mirko Zimic
Journal:  Tuberculosis (Edinb)       Date:  2013-07-16       Impact factor: 3.131

10.  Use of pyrazinamidase activity on Mycobacterium tuberculosis as a rapid method for determination of pyrazinamide susceptibility.

Authors:  J K McClatchy; A Y Tsang; M S Cernich
Journal:  Antimicrob Agents Chemother       Date:  1981-10       Impact factor: 5.191
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  11 in total

Review 1.  Systematic review of mutations in pyrazinamidase associated with pyrazinamide resistance in Mycobacterium tuberculosis clinical isolates.

Authors:  Sarah M Ramirez-Busby; Faramarz Valafar
Journal:  Antimicrob Agents Chemother       Date:  2015-06-15       Impact factor: 5.191

2.  Host-Mediated Bioactivation of Pyrazinamide: Implications for Efficacy, Resistance, and Therapeutic Alternatives.

Authors:  Laura E Via; Rada Savic; Danielle M Weiner; Matthew D Zimmerman; Brendan Prideaux; Scott M Irwin; Eddie Lyon; Paul O'Brien; Pooja Gopal; Seokyong Eum; Myungsun Lee; Jean-Philippe Lanoix; Noton K Dutta; TaeSun Shim; Jeong Su Cho; Wooshik Kim; Petros C Karakousis; Anne Lenaerts; Eric Nuermberger; Clifton E Barry; Véronique Dartois
Journal:  ACS Infect Dis       Date:  2015-05-08       Impact factor: 5.084

Review 3.  Mutations Associated with Pyrazinamide Resistance in Mycobacterium tuberculosis: A Review and Update.

Authors:  Ananthi Rajendran; Kannan Palaniyandi
Journal:  Curr Microbiol       Date:  2022-10-08       Impact factor: 2.343

4.  Selective Inactivity of Pyrazinamide against Tuberculosis in C3HeB/FeJ Mice Is Best Explained by Neutral pH of Caseum.

Authors:  Jean-Philippe Lanoix; Thomas Ioerger; Aimee Ormond; Firat Kaya; James Sacchettini; Véronique Dartois; Eric Nuermberger
Journal:  Antimicrob Agents Chemother       Date:  2015-11-16       Impact factor: 5.191

5.  A Multinational Analysis of Mutations and Heterogeneity in PZase, RpsA, and PanD Associated with Pyrazinamide Resistance in M/XDR Mycobacterium tuberculosis.

Authors:  S M Ramirez-Busby; T C Rodwell; L Fink; D Catanzaro; R L Jackson; M Pettigrove; A Catanzaro; F Valafar
Journal:  Sci Rep       Date:  2017-06-19       Impact factor: 4.379

Review 6.  Marine Natural Products and Drug Resistance in Latent Tuberculosis.

Authors:  Muhammad Tahir Khan; Aman Chandra Kaushik; Aamer Iqbal Bhatti; Yu-Juan Zhang; Shulin Zhang; Amie Jinghua Wei; Shaukat Iqbal Malik; Dong Qing Wei
Journal:  Mar Drugs       Date:  2019-09-26       Impact factor: 5.118

7.  Characterization of pncA Mutations and Prediction of PZA Resistance in Mycobacterium tuberculosis Clinical Isolates From Chongqing, China.

Authors:  Kun Li; Zhongping Yang; Jing Gu; Ming Luo; Jiaoyu Deng; Yaokai Chen
Journal:  Front Microbiol       Date:  2021-01-11       Impact factor: 5.640

8.  Detection of Mutations in pncA in Mycobacterium tuberculosis Clinical Isolates from Nepal in Association with Pyrazinamide Resistance.

Authors:  Dipti Shrestha; Bhagwan Maharjan; Jeewan Thapa; Mwangala Lonah Akapelwa; Precious Bwalya; Joseph Yamweka Chizimu; Chie Nakajima; Yasuhiko Suzuki
Journal:  Curr Issues Mol Biol       Date:  2022-09-08       Impact factor: 2.976

9.  Molecular analysis of pyrazinamide resistance in Mycobacterium tuberculosis in Vietnam highlights the high rate of pyrazinamide resistance-associated mutations in clinical isolates.

Authors:  Nguyen Quang Huy; Contamin Lucie; Tran Thi Thanh Hoa; Nguyen Van Hung; Nguyen Thi Ngoc Lan; Nguyen Thai Son; Nguyen Viet Nhung; Dang Duc Anh; Bañuls Anne-Laure; Nguyen Thi Van Anh
Journal:  Emerg Microbes Infect       Date:  2017-10-11       Impact factor: 7.163

10.  Prediction of Mycobacterium tuberculosis pyrazinamidase function based on structural stability, physicochemical and geometrical descriptors.

Authors:  Rydberg Roman Supo-Escalante; Aldhair Médico; Eduardo Gushiken; Gustavo E Olivos-Ramírez; Yaneth Quispe; Fiorella Torres; Melissa Zamudio; Ricardo Antiparra; L Mario Amzel; Robert H Gilman; Patricia Sheen; Mirko Zimic
Journal:  PLoS One       Date:  2020-07-31       Impact factor: 3.240
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