François De Guio1, Alexandre Vignaud1, Stefan Ropele1, Marco Duering1, Edouard Duchesnay1, Hugues Chabriat2, Eric Jouvent1. 1. From the Université Paris Diderot, Sorbonne Paris Cité, UMR-S 1161 INSERM, Paris, France (F.D.G., H.C., E.J.); DHU NeuroVasc Sorbonne Paris Cité, Paris, France (F.D.G., H.C., E.J.); UNIRS, Neurospin, CEA, Gif-sur-Yvette, France (A.V., E.D.); Department of Neurology, Medical University of Graz, Austria (S.R.); Institute for Stroke and Dementia Research, Ludwig-Maximilians-University, Munich, Germany (M.D.); and AP-HP, Lariboisière Hospital, Department of Neurology, Paris, France (H.C., E.J.). 2. From the Université Paris Diderot, Sorbonne Paris Cité, UMR-S 1161 INSERM, Paris, France (F.D.G., H.C., E.J.); DHU NeuroVasc Sorbonne Paris Cité, Paris, France (F.D.G., H.C., E.J.); UNIRS, Neurospin, CEA, Gif-sur-Yvette, France (A.V., E.D.); Department of Neurology, Medical University of Graz, Austria (S.R.); Institute for Stroke and Dementia Research, Ludwig-Maximilians-University, Munich, Germany (M.D.); and AP-HP, Lariboisière Hospital, Department of Neurology, Paris, France (H.C., E.J.). hugues.chabriat@lrb.aphp.fr.
Abstract
BACKGROUND AND PURPOSE: Previous pathological studies in humans or in animal models have shown alterations of small arteries and veins within white matter lesions in cerebral small vessel disease. We aimed to evaluate in vivo, the integrity of the cerebral venous network using high-resolution MRI both within and outside white matter hyperintensities in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). METHODS: High-resolution T2*-weighted images were obtained at 7-T in 13 CADASIL patients with no or only mild symptoms and 13 age- and sex-matched controls. Macroscopic veins were automatically counted in the centrum semiovale and compared between patients and controls. In addition, T2* was compared between groups in the normal-appearing white matter. RESULTS: Vein density was found lower in CADASIL patients compared with that in controls (-14.6% in patients, P<0.001). This was detected both within and outside white matter hyperintensities. Mean T2*, that is presumably inversely related to the venous density, was also found increased in normal-appearing white matter of patients (+7.2%, P=0.006). All results were independent from the extent of white matter hyperintensities. CONCLUSIONS: A significant reduction in the number of visible veins was observed in the centrum semiovale of CADASIL patients both within and outside white matter hyperintensities, together with an increase of T2* in the normal-appearing white matter. Additional studies are needed to decipher the exact implication of such vasculature changes in the appearance of white matter lesions.
BACKGROUND AND PURPOSE: Previous pathological studies in humans or in animal models have shown alterations of small arteries and veins within white matter lesions in cerebral small vessel disease. We aimed to evaluate in vivo, the integrity of the cerebral venous network using high-resolution MRI both within and outside white matter hyperintensities in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). METHODS: High-resolution T2*-weighted images were obtained at 7-T in 13 CADASIL patients with no or only mild symptoms and 13 age- and sex-matched controls. Macroscopic veins were automatically counted in the centrum semiovale and compared between patients and controls. In addition, T2* was compared between groups in the normal-appearing white matter. RESULTS: Vein density was found lower in CADASIL patients compared with that in controls (-14.6% in patients, P<0.001). This was detected both within and outside white matter hyperintensities. Mean T2*, that is presumably inversely related to the venous density, was also found increased in normal-appearing white matter of patients (+7.2%, P=0.006). All results were independent from the extent of white matter hyperintensities. CONCLUSIONS: A significant reduction in the number of visible veins was observed in the centrum semiovale of CADASIL patients both within and outside white matter hyperintensities, together with an increase of T2* in the normal-appearing white matter. Additional studies are needed to decipher the exact implication of such vasculature changes in the appearance of white matter lesions.
Authors: C E Shaaban; H J Aizenstein; D R Jorgensen; R L MacCloud; N A Meckes; K I Erickson; N W Glynn; J Mettenburg; J Guralnik; A B Newman; T S Ibrahim; P J Laurienti; A N Vallejo; C Rosano Journal: AJNR Am J Neuroradiol Date: 2017-08-03 Impact factor: 3.825
Authors: Dorothee Schoemaker; Yakeel T Quiroz; Heirangi Torrico-Teave; Joseph F Arboleda-Velasquez Journal: Neurosci Lett Date: 2019-01-08 Impact factor: 3.046
Authors: François De Guio; Sonia Reyes; Alexandre Vignaud; Marco Duering; Stefan Ropele; Edouard Duchesnay; Hugues Chabriat; Eric Jouvent Journal: PLoS One Date: 2014-08-28 Impact factor: 3.240
Authors: Hugo J Kuijf; Willem H Bouvy; Jaco J M Zwanenburg; Tom B Razoux Schultz; Max A Viergever; Koen L Vincken; Geert Jan Biessels Journal: Eur Radiol Date: 2016-02-16 Impact factor: 5.315